Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)

Stable Identifier
Reaction [transition]
Homo sapiens
Renin Hydrolyzes Angiotensinogen to Yield Angiotensin I
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Renin in the bloodstream hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I). Renin is produced in the juxtaglomerular cells of the kidney in response to reduced blood pressure. Aliskiren, a drug used clinically to treat hypertension, inhibits this reaction (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).
Literature References
PubMed ID Title Journal Year
22193701 Aliskiren displays long-lasting interactions with human renin

Danielson, UH, Sedig, S, Vrang, L, Sahlberg, C, Henderson, I, Lindström, E, Gossas, T

Naunyn Schmiedebergs Arch Pharmacol 2011
20380117 Is aliskiren superior to inhibitors of angiotensin-converting enzyme and angiotensin receptor blockers in renin-angiotensin system blockade?

Kulic, M, Gerc, V, Buksa, M, Loza, V

Med Arh 2009
4360430 Kinetics of the reaction of human renin with natural substrates and tetradecapeptide substrate

Vallotton, MB, Favre, L

Biochim Biophys Acta 1973
12927775 Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jensen, C, Fuhrer, W, Rigollier, P, Stutz, S, Grütter, MG, Rasetti, V, Cumin, F, Schnell, CR, Wood, JM, Yamaguchi, Y, Maibaum, J, Herold, P, Baum, HP, Göschke, R, Cohen, NC, Rüger, H, Bedigian, MP, Schilling, W, Rahuel, J, O'Brien, E, Mah, R, Stanton, A

Biochem Biophys Res Commun 2003
4289389 Kinetic constants of the human renin and human angiotensinogen reaction

Haas, E, Goldblatt, H

Circ Res 1967
4330891 Enzyme kinetic studies on human renin and its purified homologous substrate

Wolff, HP, Dahlheim, H, Weber, P, Rosenthal, J

Am J Physiol 1971
12045255 Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

Delarue, F, Giller, T, Nguyen, G, Sraer, JD, Burcklé, C, Bouzhir, L

J Clin Invest 2002
4322712 Kinetics of the human renin and human substrate reaction

Green, D, Gould, AB

Cardiovasc Res 1971
Event Information
Go Biological Process
Catalyst Activity

aspartic-type endopeptidase activity of Renin [extracellular region]

This event is regulated
Negatively by
Orthologous Events
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