Reactome | Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)

Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)

Stable Identifier

R-HSA-2022412

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Renin Hydrolyzes Angiotensinogen to Yield Angiotensin I

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Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)

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Renin in the bloodstream hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I). Renin is produced in the juxtaglomerular cells of the kidney in response to reduced blood pressure. Aliskiren, a drug used clinically to treat hypertension, inhibits this reaction (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
22193701	Aliskiren displays long-lasting interactions with human renin Danielson, UH, Sedig, S, Vrang, L, Sahlberg, C, Henderson, I, Lindström, E, Gossas, T	Naunyn Schmiedebergs Arch Pharmacol	2011
20380117	Is aliskiren superior to inhibitors of angiotensin-converting enzyme and angiotensin receptor blockers in renin-angiotensin system blockade? Kulic, M, Gerc, V, Buksa, M, Loza, V	Med Arh	2009
4360430	Kinetics of the reaction of human renin with natural substrates and tetradecapeptide substrate Vallotton, MB, Favre, L	Biochim Biophys Acta	1973
12927775	Structure-based design of aliskiren, a novel orally effective renin inhibitor Jensen, C, Fuhrer, W, Rigollier, P, Stutz, S, Grütter, MG, Rasetti, V, Cumin, F, Schnell, CR, Wood, JM, Yamaguchi, Y, Maibaum, J, Herold, P, Baum, HP, Göschke, R, Cohen, NC, Rüger, H, Bedigian, MP, Schilling, W, Rahuel, J, O'Brien, E, Mah, R, Stanton, A	Biochem Biophys Res Commun	2003
4289389	Kinetic constants of the human renin and human angiotensinogen reaction Haas, E, Goldblatt, H	Circ Res	1967
4330891	Enzyme kinetic studies on human renin and its purified homologous substrate Wolff, HP, Dahlheim, H, Weber, P, Rosenthal, J	Am J Physiol	1971
12045255	Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin Delarue, F, Giller, T, Nguyen, G, Sraer, JD, Burcklé, C, Bouzhir, L	J Clin Invest	2002
4322712	Kinetics of the human renin and human substrate reaction Green, D, Gould, AB	Cardiovasc Res	1971