UniProt:Q9Y6X5 ENPP4

chain
  • signal peptide:1-15
  • chain:16-453
checksum BC82FA36D9B587C4
comment
  • FUNCTION Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.CATALYTIC ACTIVITY P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)COFACTOR Binds 2 Zn(2+) ions per subunit.SUBCELLULAR LOCATION Expressed on the surface of vascular endothelia.SIMILARITY Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 228329
description
  • recommendedName: Bis(5'-adenosyl)-triphosphatase ENPP4 ecNumber: 3.6.1.29 alternativeName: AP3A hydrolase shortName: AP3Aase alternativeName: Ectonucleotide pyrophosphatase/phosphodiesterase family member 4 shortName: E-NPP 4 shortName: NPP-4
displayName UniProt:Q9Y6X5 ENPP4
geneName
  • ENPP4
  • KIAA0879
  • NPP4
identifier Q9Y6X5
isSequenceChanged false
keyword
  • 3D-structure
  • Blood coagulation
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Hemostasis
  • Hydrolase
  • Membrane
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
  • Zinc
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • ENPP4
otherIdentifier
  • 11736142_at
  • 11736143_s_at
  • 11736144_at
  • 17009316
  • 204160_PM_s_at
  • 204160_s_at
  • 204161_PM_s_at
  • 204161_s_at
  • 22875
  • 2909023
  • 2909024
  • 2909025
  • 2909026
  • 2909027
  • 2909028
  • 2909029
  • 2909030
  • 2909033
  • 2909034
  • 2909035
  • 2909036
  • 2909037
  • 2909038
  • 2909039
  • 36459_at
  • 8120061
  • A_14_P200196
  • A_23_P70318
  • GE58605
  • GO:0005515
  • GO:0005886
  • GO:0007596
  • GO:0007599
  • GO:0016020
  • GO:0016787
  • GO:0030194
  • GO:0046130
  • GO:0046872
  • GO:0047710
  • GO:0055086
  • GO:0070062
  • GO:0101003
  • GO:1901135
  • HMNXSV003051859
  • Hs.54037.0.S1_3p_a_at
  • ILMN_1781761
  • PH_hs_0003555
  • PH_hs_0040712
  • TC06000624.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ENPP4_HUMAN
  • A8K5G1
  • Q7L2N1
sequenceLength 453
species [Species:48887] Homo sapiens
stId uniprot:Q9Y6X5
url http://purl.uniprot.org/uniprot/Q9Y6X5
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