UniProt:Q9Y6X3 MAU2

chain
  • chain:1-613
checksum 47E33F5CE6504047
comment
  • FUNCTION Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28167679). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16682347, PubMed:16802858).SUBUNIT Heterodimerizes with MAU2/SCC2 to form the cohesin loading complex (PubMed:16682347, PubMed:16802858, PubMed:21934712, PubMed:22628566, PubMed:28167679). The NIPBL-MAU2 heterodimer interacts with the SMC1A-SMC3 heterodimer and with the cohesin complex composed of SMC1A, SMC3, RAD21 and STAG1 (PubMed:22628566). Interacts with PRR12 (PubMed:39742660).SUBCELLULAR LOCATION Binds to chromatin from the end of mitosis until prophase.ALTERNATIVE PRODUCTS Belongs to the SCC4/mau-2 family.SEQUENCE CAUTION Extended N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 233522
description
  • recommendedName: MAU2 chromatid cohesion factor homolog shortName: MAU-2 alternativeName: Cohesin loading complex subunit SCC4 homolog
displayName UniProt:Q9Y6X3 MAU2
geneName
  • MAU2
  • KIAA0892
  • SCC4
identifier Q9Y6X3
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell cycle
  • Cell division
  • Chromosome
  • Chromosome partition
  • Mitosis
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repeat
  • TPR repeat
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • MAU2
otherIdentifier
  • 11725461_s_at
  • 11725462_at
  • 11725463_x_at
  • 16859990
  • 212505_PM_s_at
  • 212505_s_at
  • 216926_PM_s_at
  • 216926_s_at
  • 217652_PM_at
  • 217652_at
  • 227465_PM_at
  • 227465_at
  • 23383
  • 36054_at
  • 36056_g_at
  • 3825651
  • 3825652
  • 3825653
  • 3825664
  • 3825665
  • 3825666
  • 3825667
  • 3825668
  • 3825669
  • 3825671
  • 3825672
  • 3825673
  • 3825674
  • 3825675
  • 3825676
  • 3825677
  • 3825678
  • 3825679
  • 3825680
  • 3825681
  • 3825682
  • 3825683
  • 3825684
  • 3825685
  • 3825686
  • 3825687
  • 3825688
  • 3825689
  • 3825690
  • 3825691
  • 3825692
  • 3825693
  • 3825695
  • 3825696
  • 3825697
  • 3825698
  • 3825700
  • 3825701
  • 3825702
  • 3825703
  • 49224_at
  • 8027184
  • 88998_at
  • A_32_P8361
  • A_32_P8365
  • GE53565
  • GO:0000785
  • GO:0003824
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0007059
  • GO:0007064
  • GO:0016604
  • GO:0032116
  • GO:0034088
  • GO:0051301
  • GO:0061775
  • GO:0090694
  • GO:0140097
  • HMNXSV003025963
  • HMNXSV003058386
  • Hs.112751.0.A1_3p_at
  • Hs.112751.1.A1_3p_a_at
  • Hs.112751.3.A1_3p_a_at
  • Hs.270982.0.A1_3p_at
  • ILMN_1685631
  • PH_hs_0032912
  • PH_hs_0035292
  • TC19000372.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SCC4_HUMAN
  • Q66PT1
  • Q6P3S7
  • Q6ZTT2
  • Q9UFX8
sequenceLength 613
species [Species:48887] Homo sapiens
stId uniprot:Q9Y6X3
url http://purl.uniprot.org/uniprot/Q9Y6X3
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