UniProt:Q9Y6N5 SQOR

chain
  • transit peptide:1-
  • chain:-450
checksum 943ABD4049E3634D
comment
  • FUNCTION Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro) (PubMed:22852582). It is believed the in vivo electron acceptor is glutathione (PubMed:25225291, PubMed:29715001).CATALYTIC ACTIVITY ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfateCATALYTIC ACTIVITY a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinolCATALYTIC ACTIVITY ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10COFACTOR Binds 1 FAD per subunit.BIOPHYSICOCHEMICAL PROPERTIES The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SQRD family.
crossReference
databaseName UniProt
dbId 65012
description
  • recommendedName: fullName evidence="10"Sulfide:quinone oxidoreductase, mitochondrial shortName evidence="11"SQOR ecNumber evidence="4"1.8.5.8 alternativeName: Sulfide dehydrogenase-like alternativeName: fullName evidence="11"Sulfide quinone oxidoreductase
displayName UniProt:Q9Y6N5 SQOR
geneName
  • SQOR
  • SQRDL
  • CGI-44
identifier Q9Y6N5
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Disease variant
  • Disulfide bond
  • FAD
  • Flavoprotein
  • Mitochondrion
  • Oxidoreductase
  • Phosphoprotein
  • Proteomics identification
  • Quinone
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • SQOR
otherIdentifier
  • 11718515_a_at
  • 16800680
  • 217995_PM_at
  • 217995_at
  • 3592512
  • 3592513
  • 3592514
  • 3592515
  • 3592516
  • 3592517
  • 3592518
  • 3592519
  • 3592521
  • 3592522
  • 3592523
  • 3592524
  • 3592525
  • 3592526
  • 3592528
  • 3592529
  • 3592530
  • 3592531
  • 3592534
  • 3592535
  • 3592536
  • 3592537
  • 3592542
  • 3592543
  • 46305_at
  • 58472
  • 7983512
  • A_23_P3221
  • GE79664
  • GO:0005515
  • GO:0005739
  • GO:0005743
  • GO:0006790
  • GO:0016491
  • GO:0048038
  • GO:0070221
  • GO:0070224
  • GO:0071949
  • GO:0106436
  • HMNXSV003001729
  • ILMN_1667199
  • PH_hs_0025406
  • PH_hs_0033367
  • TC15000364.hg
  • g10864010_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SQOR_HUMAN
  • Q9UQM8
sequenceLength 450
species [Species:48887] Homo sapiens
stId uniprot:Q9Y6N5
url http://purl.uniprot.org/uniprot/Q9Y6N5
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