UniProt:Q9Y6M7 SLC4A7

chain
  • chain:1-1214
checksum 7B4ADA1E3F26813C
comment
  • FUNCTION Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404).FUNCTION Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis.CATALYTIC ACTIVITY hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)CATALYTIC ACTIVITY hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)ACTIVITY REGULATION Transporter activity is regulated by CA2/carbonic anhydrase 2, cAMP and PKA. Insensitive to stilbene derivatives. Inhibited by 5-(N-ethyl-N-isopropyl)-amiloride (EIPA).BIOPHYSICOCHEMICAL PROPERTIES Interacts with CFTR through NHERF1/EBP50. Interacts with USH1C. Forms a complex with ATP6V1B1 and NHERF1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2.SUBCELLULAR LOCATION Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity).SUBCELLULAR LOCATION Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney.TISSUE SPECIFICITY Expressed in skeletal muscle and heart muscle.INDUCTION In response to growth factor stimuli, mTORC1 activation, through the RPS6KA1-dependent EIF4B phosphorylation, stimulates SLC4A7 mRNA translation (at protein level) (PubMed:35772404). Strongly induced upon macrophage differentiation (PubMed:29779931).DOMAIN The PDZ-binding motif mediates interaction with the CFTR, NHERF1/EBP50 complex and probably with USH1C.SIMILARITY Belongs to the anion exchanger (TC 2.A.31) family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 247298
description
  • recommendedName: Sodium bicarbonate cotransporter 3 alternativeName: Electroneutral Na/HCO(3) cotransporter alternativeName: Sodium bicarbonate cotransporter 2 alternativeName: Sodium bicarbonate cotransporter 2b shortName: Bicarbonate transporter alternativeName: Solute carrier family 4 member 7
displayName UniProt:Q9Y6M7 SLC4A7
geneName
  • SLC4A7
  • BT
  • NBC2
  • NBC2B
  • NBC3
  • NBCn1
  • SBC2
  • SLC4A6
identifier Q9Y6M7
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Disulfide bond
  • Glycoprotein
  • Ion transport
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Sodium
  • Sodium transport
  • Symport
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • SLC4A7
otherIdentifier
  • 11727279_s_at
  • 11747964_a_at
  • 16951756
  • 207603_PM_at
  • 207604_PM_s_at
  • 207604_s_at
  • 209884_PM_s_at
  • 209884_s_at
  • 210286_PM_s_at
  • 210286_s_at
  • 2666902
  • 2666903
  • 2666905
  • 2666906
  • 2666907
  • 2666908
  • 2666911
  • 2666912
  • 2666913
  • 2666914
  • 2666915
  • 2666916
  • 2666918
  • 2666919
  • 2666920
  • 2666921
  • 2666922
  • 2666923
  • 2666924
  • 2666925
  • 2666926
  • 2666927
  • 2666928
  • 2666929
  • 2666930
  • 2666934
  • 2666936
  • 2666938
  • 2666939
  • 2666940
  • 2666941
  • 2666942
  • 2666944
  • 2666945
  • 2666946
  • 2666947
  • 2666949
  • 2666951
  • 2666953
  • 2666956
  • 2666957
  • 2666959
  • 2666961
  • 2666962
  • 2666963
  • 2666969
  • 34936_at
  • 54598_r_at
  • 56632_r_at
  • 69487_at
  • 8085914
  • 9497
  • A_23_P132468
  • A_24_P362931
  • A_24_P368575
  • GE81310
  • GO:0005452
  • GO:0005515
  • GO:0005886
  • GO:0006164
  • GO:0006221
  • GO:0006811
  • GO:0006814
  • GO:0006820
  • GO:0008509
  • GO:0008510
  • GO:0015106
  • GO:0015291
  • GO:0015293
  • GO:0015698
  • GO:0015701
  • GO:0016020
  • GO:0016323
  • GO:0016324
  • GO:0032420
  • GO:0035725
  • GO:0042995
  • GO:0048856
  • GO:0051453
  • GO:0055085
  • GO:0055086
  • GO:0060117
  • GO:0071363
  • GO:0090383
  • GO:0098656
  • HMNXSV003022987
  • ILMN_1808354
  • ILMN_2200917
  • PH_hs_0028028
  • TC03001255.hg
  • g4507028_3p_a_at
  • g5051627_3p_a_at
  • g6650103_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • S4A7_HUMAN
  • A6NIA8
  • B2CI53
  • B5M449
  • B5M451
  • B5M452
  • B5M453
  • B6DY52
  • B6DY53
  • C9JST9
  • D3K174
  • D3K175
  • O60350
  • Q6AHZ9
  • Q9HC88
  • Q9UIB9
sequenceLength 1214
species [Species:48887] Homo sapiens
stId uniprot:Q9Y6M7
url http://purl.uniprot.org/uniprot/Q9Y6M7
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