Reactome | UniProt:Q9Y6E0 STK24

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UniProt:Q9Y6E0 STK24 Show undefined attributes

chain	chain:1-443 chain:1-325 chain:326-443 initiator methionine:1
checksum	4A9FF1F6B6A88A97
comment	FUNCTION Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Monomer (PubMed:20124694). Interacts with CTTNBP2NL (PubMed:18782753). Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006). Interacts with PDCD10; this interaction is required for the association of STK24 with RIPOR1 (PubMed:27807006). Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26 (PubMed:18782753).SUBCELLULAR LOCATION The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.ALTERNATIVE PRODUCTS Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.PTM Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis.PTM Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is on both serine and threonine residues.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
crossReference	[DatabaseIdentifier:12119602] OpenTargets:ENSG00000102572 [DatabaseIdentifier:12818178] ZINC - World Drugs:STK24_HUMAN [DatabaseIdentifier:12814522] ZINC target:Q9Y6E0 [DatabaseIdentifier:12811210] ZINC - Substances:STK24_HUMAN [DatabaseIdentifier:12808641] ZINC - Predictions - Purchasable:STK24_HUMAN [DatabaseIdentifier:12806674] ZINC - Investigational:STK24_HUMAN [DatabaseIdentifier:12805606] ZINC - FDA approved:STK24_HUMAN [DatabaseIdentifier:12804458] ZINC - Biogenic:STK24_HUMAN [DatabaseIdentifier:12439411] RefSeq:NP_003567.2 [DatabaseIdentifier:12439412] RefSeq:NP_001027467.2 [DatabaseIdentifier:12279940] Pharos - Targets:Q9Y6E0 [DatabaseIdentifier:12258142] PRO:Q9Y6E0 [DatabaseIdentifier:12142122] PDB:7B34 [DatabaseIdentifier:12142123] PDB:3ZHP [DatabaseIdentifier:12142137] PDB:4QMO [DatabaseIdentifier:12142124] PDB:4QMP [DatabaseIdentifier:12142145] PDB:4QO9 [DatabaseIdentifier:12142125] PDB:4QMQ [DatabaseIdentifier:12142144] PDB:8QLT [DatabaseIdentifier:12142132] PDB:8BZJ [DatabaseIdentifier:12142126] PDB:4QMS [DatabaseIdentifier:12142127] PDB:4U8Z [DatabaseIdentifier:12142138] PDB:4W8E [DatabaseIdentifier:12142133] PDB:8BZI [DatabaseIdentifier:12142141] PDB:4O27 [DatabaseIdentifier:12142142] PDB:3A7J [DatabaseIdentifier:12142139] PDB:4W8D [DatabaseIdentifier:12142136] PDB:4QMN [DatabaseIdentifier:12142129] PDB:4QMU [DatabaseIdentifier:12142131] PDB:4QMW [DatabaseIdentifier:12142130] PDB:4QMV [DatabaseIdentifier:12142140] PDB:3A7I [DatabaseIdentifier:12142135] PDB:4QMM [DatabaseIdentifier:12142128] PDB:4QMT [DatabaseIdentifier:12142134] PDB:4QML [DatabaseIdentifier:12142143] PDB:8QLS [DatabaseIdentifier:12142116] PDB:4QMY [DatabaseIdentifier:12142120] PDB:7B32 [DatabaseIdentifier:12142119] PDB:7B33 [DatabaseIdentifier:12142108] PDB:3A7F [DatabaseIdentifier:12142111] PDB:3A7G [DatabaseIdentifier:12142117] PDB:7B30 [DatabaseIdentifier:12142109] PDB:3CKX [DatabaseIdentifier:12142107] PDB:8QLQ [DatabaseIdentifier:12142110] PDB:8QLR [DatabaseIdentifier:12142115] PDB:7B31 [DatabaseIdentifier:12142121] PDB:7B35 [DatabaseIdentifier:12142114] PDB:4QMX [DatabaseIdentifier:12142112] PDB:3A7H [DatabaseIdentifier:12142113] PDB:4QNA [DatabaseIdentifier:12142106] PDB:3CKW [DatabaseIdentifier:12142118] PDB:4QMZ [DatabaseIdentifier:11504968] ENSEMBL:ENSG00000102572 [DatabaseIdentifier:11617310] ENSEMBL:ENSP00000365730 [DatabaseIdentifier:11617311] ENSEMBL:ENSP00000442539 [DatabaseIdentifier:11740009] ENSEMBL:ENST00000539966 [DatabaseIdentifier:11740010] ENSEMBL:ENST00000376547 [DatabaseIdentifier:11779166] Guide to Pharmacology - Targets:2217 [DatabaseIdentifier:11782028] GeneCards:STK24 [DatabaseIdentifier:11797704] GlyGen:Q9Y6E0 [DatabaseIdentifier:11829507] HMDB Protein:HMDBP01373 [DatabaseIdentifier:11835149] HPA:ENSG00000102572-STK24
databaseName	UniProt
dbId	65132
description	recommendedName: Serine/threonine-protein kinase 24 ecNumber: 2.7.11.1 alternativeName: Mammalian STE20-like protein kinase 3 shortName: MST-3 alternativeName: STE20-like kinase MST3 component recommendedName: Serine/threonine-protein kinase 24 36 kDa subunit alternativeName: Mammalian STE20-like protein kinase 3 N-terminal shortName: MST3/N /component component recommendedName: Serine/threonine-protein kinase 24 12 kDa subunit alternativeName: Mammalian STE20-like protein kinase 3 C-terminal shortName: MST3/C /component
displayName	UniProt:Q9Y6E0 STK24
geneName	STK24 MST3 STK3
identifier	Q9Y6E0
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Apoptosis ATP-binding Cytoplasm Kinase Magnesium Membrane Metal-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	STK24
otherIdentifier	11729133_a_at 11729134_s_at 11729135_a_at 11729136_a_at 1562425_PM_at 1562425_at 1562426_PM_a_at 1562426_a_at 16780456 208854_PM_s_at 208854_s_at 208855_PM_s_at 208855_s_at 215188_PM_at 215188_at 3522220 3522222 3522224 3522226 3522227 3522228 3522229 3522230 3522231 3522232 3522233 3522234 3522235 3522240 3522242 3522243 3522245 3522246 3522247 3522248 3522250 3522259 3522260 3522261 3522262 3522263 3522270 3522277 3522278 3522279 3522280 3522295 3522296 3522297 3522298 4023403 4023422 40473_at 49200_at 51336_at 75644_r_at 7972444 8428 A_23_P253177 A_23_P60683 A_24_P73389 GE54189 GE756719 GE87768 GO:0000166 GO:0003824 GO:0004672 GO:0004674 GO:0005515 GO:0005524 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005794 GO:0005829 GO:0006468 GO:0006915 GO:0007165 GO:0008631 GO:0009267 GO:0016020 GO:0016301 GO:0016740 GO:0030336 GO:0034599 GO:0035556 GO:0045296 GO:0046777 GO:0046872 GO:0048679 GO:0070062 GO:0090443 GO:0097194 GO:0106310 GO:0140096 HMNXSV003046480 Hs.168913.1.A1_3p_a_at Hs.270256.0.A1_3p_at Hs2.232864.1.A1_3p_at Hs2.232864.1.A1_3p_x_at ILMN_1655163 ILMN_1695773 ILMN_1702723 PH_hs_0010078 TC13000822.hg g5326765_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-351829] STK24 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-351892] STK24(1-325) [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-351898] STK24(326-443) [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-351944] STK24(1-325) [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000102572] ENSEMBL:ENSG00000102572 STK24 [ReferenceDNASequence:12705563] UCSC:Q9Y6E0 STK24 [ReferenceDNASequence:11370494] BioGPS Gene:8428 STK24 [ReferenceDNASequence:11395098] COSMIC - genes:STK3 STK24 [ReferenceDNASequence:11395097] COSMIC - genes:STK24 STK24 [ReferenceDNASequence:11405255] CTD Gene:8428 STK24 [ReferenceDNASequence:11431271] dbSNP Gene:8428 STK24 [ReferenceDNASequence:11813629] HGNC:11403 STK24 [ReferenceDNASequence:11908619] KEGG:hsa:8428 STK24 [ReferenceDNASequence:12000283] Monarch:8428 STK24 [ReferenceDNASequence:12084376] NCBI Gene:8428 STK24 [ReferenceDNASequence:12105490] OMIM:604984 STK24
referenceTranscript	[ReferenceRNASequence:12620924] RefSeq:NM_003576.4 STK24 [ReferenceRNASequence:12620923] RefSeq:NM_001032296.4 STK24
schemaClass	ReferenceGeneProduct
secondaryIdentifier	STK24_HUMAN O14840 Q5JV92
sequenceLength	443
species	[Species:48887] Homo sapiens
stId	uniprot:Q9Y6E0
url	http://purl.uniprot.org/uniprot/Q9Y6E0

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