UniProt:Q9Y466 NR2E1

chain
  • chain:1-385
checksum 39181A42A2FB79C2
comment
  • FUNCTION Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.SUBUNIT Monomer. Interacts with ATN1; the interaction represses the transcription.SUBCELLULAR LOCATION Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.SIMILARITY Belongs to the nuclear hormone receptor family. NR2 subfamily.
crossReference
databaseName UniProt
dbId 60430
description
  • recommendedName: Nuclear receptor subfamily 2 group E member 1 alternativeName: Nuclear receptor TLX alternativeName: Protein tailless homolog shortName: Tll shortName: hTll
displayName UniProt:Q9Y466 NR2E1
geneName
  • NR2E1
  • TLX
identifier Q9Y466
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • Alternative splicing
  • Developmental protein
  • DNA-binding
  • Metal-binding
  • Nucleus
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • NR2E1
otherIdentifier
  • 11733365_a_at
  • 11733366_a_at
  • 17011397
  • 207443_PM_at
  • 207443_at
  • 2920328
  • 2920329
  • 2920330
  • 2920331
  • 2920332
  • 2920333
  • 2920334
  • 2920337
  • 2920344
  • 2920345
  • 2920347
  • 2920348
  • 2920349
  • 2920350
  • 2920351
  • 2920353
  • 2920354
  • 2920355
  • 2920356
  • 2920357
  • 34125_at
  • 7101
  • 8121334
  • 81508_at
  • A_14_P135140
  • A_23_P338372
  • GE81256
  • GO:0000122
  • GO:0000785
  • GO:0000978
  • GO:0000981
  • GO:0001227
  • GO:0001228
  • GO:0001525
  • GO:0001662
  • GO:0002052
  • GO:0002118
  • GO:0003677
  • GO:0003700
  • GO:0003707
  • GO:0004879
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0006355
  • GO:0006915
  • GO:0007399
  • GO:0007405
  • GO:0007420
  • GO:0007601
  • GO:0008270
  • GO:0008283
  • GO:0008284
  • GO:0019899
  • GO:0021542
  • GO:0021764
  • GO:0021772
  • GO:0021819
  • GO:0021872
  • GO:0021895
  • GO:0021953
  • GO:0021960
  • GO:0021987
  • GO:0030154
  • GO:0030198
  • GO:0030518
  • GO:0030522
  • GO:0035019
  • GO:0035176
  • GO:0042826
  • GO:0043010
  • GO:0043066
  • GO:0043565
  • GO:0043615
  • GO:0045165
  • GO:0045665
  • GO:0045766
  • GO:0045787
  • GO:0045944
  • GO:0046872
  • GO:0048708
  • GO:0048712
  • GO:0048814
  • GO:0048856
  • GO:0048870
  • GO:0050877
  • GO:0060041
  • GO:0060164
  • GO:0060291
  • GO:0061351
  • GO:0090049
  • GO:1990837
  • GO:2000178
  • GO:2000179
  • GO:2000648
  • HMNXSV003025427
  • ILMN_1738580
  • ILMN_2094294
  • PH_hs_0001977
  • TC06000860.hg
  • TC06000861.hg
  • g11141398_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NR2E1_HUMAN
  • Q6ZMP8
sequenceLength 385
species [Species:48887] Homo sapiens
stId uniprot:Q9Y466
url http://purl.uniprot.org/uniprot/Q9Y466
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