UniProt:Q9Y345 SLC6A5

chain
  • chain:1-797
checksum 47D8A9B179896CE0
comment
  • FUNCTION Sodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:9845349). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:9845349).FUNCTION Lacks sodium- and chloride-dependent glycine transporter activity.FUNCTION Lacks sodium- and chloride-dependent glycine transporter activity.CATALYTIC ACTIVITY glycine(out) + chloride(out) + 3 Na(+)(out) = glycine(in) + chloride(in) + 3 Na(+)(in)BIOPHYSICOCHEMICAL PROPERTIES Expressed in medulla, and to a lesser extent in spinal cord and cerebellum.PTM N-glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily.
crossReference
databaseName UniProt
dbId 64078
description
  • recommendedName: Sodium- and chloride-dependent glycine transporter 2 shortName: GlyT-2 shortName: GlyT2 alternativeName: Solute carrier family 6 member 5
displayName UniProt:Q9Y345 SLC6A5
geneName
  • SLC6A5
  • GLYT2
  • NET1
identifier Q9Y345
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Membrane
  • Metal-binding
  • Neurotransmitter transport
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Sodium
  • Symport
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • SLC6A5
otherIdentifier
  • 11735289_a_at
  • 16722825
  • 210810_PM_s_at
  • 210810_s_at
  • 236508_PM_at
  • 236508_at
  • 33028_at
  • 3323516
  • 3323517
  • 3323519
  • 3323520
  • 3323521
  • 3323524
  • 3323525
  • 3323526
  • 3323527
  • 3323532
  • 3323533
  • 3323536
  • 3323537
  • 3323538
  • 3323539
  • 3323540
  • 3323545
  • 3323547
  • 3323549
  • 3323550
  • 3323551
  • 3323552
  • 3323553
  • 3323555
  • 7938907
  • 80321_at
  • 9152
  • A_14_P113842
  • A_14_P114336
  • A_23_P116624
  • GE54742
  • GE868385
  • GO:0005768
  • GO:0005886
  • GO:0006836
  • GO:0007268
  • GO:0015293
  • GO:0015375
  • GO:0016020
  • GO:0022857
  • GO:0031045
  • GO:0035725
  • GO:0045202
  • GO:0046872
  • GO:0055085
  • GO:0060012
  • GO:1903804
  • HMNXSV003027987
  • Hs.147546.0.A1_3p_at
  • PH_hs_0008239
  • TC11000258.hg
  • g4689409_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SC6A5_HUMAN
  • O95288
  • Q4VAM7
  • Q9BX77
sequenceLength 797
species [Species:48887] Homo sapiens
stId uniprot:Q9Y345
url http://purl.uniprot.org/uniprot/Q9Y345
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