UniProt:Q9Y2W2 WBP11

chain
  • chain:1-641
checksum C94F9687D132CE77
comment
  • FUNCTION Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.SUBUNIT Interacts with PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts via the PGR motif with PQBP1 in the nucleus. Interacts with the WW domains of WBP4.SUBCELLULAR LOCATION Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.TISSUE SPECIFICITY Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung.DISEASE The disease is caused by variants affecting the gene represented in this entry.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 254489
description
  • recommendedName: fullName evidence="11"WW domain-binding protein 11 shortName: WBP-11 alternativeName: Npw38-binding protein shortName: NpwBP alternativeName: SH3 domain-binding protein SNP70 alternativeName: Splicing factor that interacts with PQBP-1 and PP1
displayName UniProt:Q9Y2W2 WBP11
geneName
  • WBP11
  • NPWBP
  • SIPP1
  • SNP70
identifier Q9Y2W2
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Coiled coil
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Isopeptide bond
  • Methylation
  • mRNA processing
  • mRNA splicing
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • rRNA processing
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • WBP11
otherIdentifier
  • 11742858_s_at
  • 11745796_a_at
  • 11747310_a_at
  • 11747311_s_at
  • 11747312_x_at
  • 11758410_s_at
  • 16761789
  • 217821_PM_s_at
  • 217821_s_at
  • 217822_PM_at
  • 217822_at
  • 244647_PM_at
  • 244647_at
  • 2504542
  • 2504544
  • 3445667
  • 3445669
  • 3445671
  • 3445672
  • 3445673
  • 3445674
  • 3445675
  • 3445676
  • 3445678
  • 3445679
  • 3445680
  • 3445682
  • 3445683
  • 3445684
  • 3445687
  • 3445688
  • 3445690
  • 3445691
  • 3445692
  • 3445693
  • 3445694
  • 3445695
  • 3445696
  • 3445698
  • 3445699
  • 3445701
  • 3783886
  • 3783891
  • 3783892
  • 3783893
  • 3982743
  • 3982747
  • 3982749
  • 48983_at
  • 50640_at
  • 51729
  • 60997_r_at
  • 75895_at
  • 78140_at
  • 7961489
  • A_23_P105519
  • A_33_P3396224
  • GE491346
  • GE519333
  • GE53755
  • GE86946
  • GO:0003677
  • GO:0003697
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0006364
  • GO:0006396
  • GO:0006397
  • GO:0008380
  • GO:0016071
  • GO:0050699
  • HMNXSV003035108
  • Hs.164526.0.A1_3p_at
  • ILMN_1661051
  • ILMN_1756939
  • ILMN_1766435
  • PH_hs_0012426
  • PH_hs_0022777
  • PH_hs_0031947
  • TC12001273.hg
  • g4836400_3p_a_at
  • g7706500_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • WBP11_HUMAN
  • Q96AY8
sequenceLength 641
species [Species:48887] Homo sapiens
stId uniprot:Q9Y2W2
url http://purl.uniprot.org/uniprot/Q9Y2W2

Referrals

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