UniProt:Q9Y248 GINS2

chain
  • chain:1-185
checksum 4F6A18B1ED76F93C
comment
  • FUNCTION Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232).SUBUNIT Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4 (PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:32453425). Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro (PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (PubMed:32453425, PubMed:34694004, PubMed:34700328).SUBCELLULAR LOCATION Associates with chromatin.MASS SPECTROMETRY This is the measured mass for the GINS complex.SIMILARITY Belongs to the GINS2/PSF2 family.
crossReference
databaseName UniProt
dbId 99147
description
  • recommendedName: DNA replication complex GINS protein PSF2 alternativeName: GINS complex subunit 2
displayName UniProt:Q9Y248 GINS2
geneName
  • GINS2
  • PSF2
  • CGI-122
  • DC5
  • HSPC037
identifier Q9Y248
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Chromosome
  • DNA replication
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • GINS2
otherIdentifier
  • 11743513_a_at
  • 1557595_PM_at
  • 1557595_at
  • 16828886
  • 221521_PM_s_at
  • 221521_s_at
  • 243136_PM_at
  • 243136_at
  • 3703109
  • 3703110
  • 3703111
  • 3703113
  • 3703114
  • 3703115
  • 3703116
  • 3703117
  • 3703118
  • 3703119
  • 3703122
  • 3703123
  • 3703124
  • 3703125
  • 3703126
  • 3703127
  • 3703128
  • 3905440
  • 3905444
  • 48827_at
  • 51659
  • 72598_at
  • 73010_at
  • 8003204
  • A_23_P118246
  • GE58679
  • GO:0000228
  • GO:0000727
  • GO:0000811
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0006260
  • GO:0006281
  • GO:0006310
  • GO:0071162
  • Hs.222171.0.A1_3p_at
  • Hs2.429227.1.S1_3p_s_at
  • ILMN_1809590
  • PH_hs_0020095
  • TC16001318.hg
  • g13112024_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PSF2_HUMAN
  • D3DUM5
  • Q6IAG9
sequenceLength 185
species [Species:48887] Homo sapiens
stId uniprot:Q9Y248
url http://purl.uniprot.org/uniprot/Q9Y248
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