Reactome | UniProt:Q9WV92 Epb41l3

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UniProt:Q9WV92 Epb41l3 Show undefined attributes

chain	chain:1-929 initiator methionine:1 chain:2-929
checksum	F4975FF405DA44AE
comment	FUNCTION Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5 (By similarity).SUBUNIT Interacts (via FERM domain) with CADM1. Interacts (via FERM domain) with PRMT3; the interaction is direct and inhibits the protein-arginine N-methyltransferase activity of PRMT3. Interacts with PRMT5. Interacts with PRMT6.SUBUNIT Has the complete spectrin--actin-binding (SAB) domain and fully interacts with spectrin and actin.SUBCELLULAR LOCATION Detected in the cytoplasm of actively dividing cells.ALTERNATIVE PRODUCTS Experimental confirmation may be lacking for some isoforms.TISSUE SPECIFICITY Detected in brain (at protein level). Highest expression in brain, lower in testis, adrenal gland, heart and kidney. Also present in muscle and epithelial cells. Isoform 1 is expressed in brain, isoform 2 is expressed in heart and isoform 3 is mostly expressed in kidney but also in heart and brain. Isoform 6 seems to be most abundant in kidney while isoform 4 and isoform 5 are predominantly expressed in heart and brain.MISCELLANEOUS The complete SAB domain is present only in the heart-specific isoforms (isoform 2 and isoform 5).MISCELLANEOUS Inferred from the cDNA sequence of Ref.2.SEQUENCE CAUTION Truncated N-terminus.
crossReference	[DatabaseIdentifier:12312452] RefSeq:NP_001342665.1 [DatabaseIdentifier:12312446] RefSeq:XP_030105343.1 [DatabaseIdentifier:12312447] RefSeq:XP_030105354.1 [DatabaseIdentifier:12312451] RefSeq:XP_030105349.1 [DatabaseIdentifier:12312448] RefSeq:NP_001411688.1 [DatabaseIdentifier:12312450] RefSeq:NP_038841.1 [DatabaseIdentifier:12312449] RefSeq:XP_030105347.1 [DatabaseIdentifier:12240245] PRO:Q9WV92 [DatabaseIdentifier:11930437] MGI:103008 [DatabaseIdentifier:11800003] GlyGen:Q9WV92 [DatabaseIdentifier:11655932] ENSEMBL:ENSMUST00000112680 [DatabaseIdentifier:11655933] ENSEMBL:ENSMUST00000080208 [DatabaseIdentifier:11533234] ENSEMBL:ENSMUSP00000079098 [DatabaseIdentifier:11533233] ENSEMBL:ENSMUSP00000108300 [DatabaseIdentifier:11446037] ENSEMBL:ENSMUSG00000024044
databaseName	UniProt
dbId	89582
description	recommendedName: Band 4.1-like protein 3 alternativeName: 4.1B alternativeName: Differentially expressed in adenocarcinoma of the lung protein 1 shortName: DAL-1 shortName: DAL1P shortName: mDAL-1 alternativeName: fullName evidence="10"Erythrocyte membrane protein band 4.1-like 3 component recommendedName: Band 4.1-like protein 3, N-terminally processed /component
displayName	UniProt:Q9WV92 Epb41l3
geneName	Epb41l3 Dal1 Epb4.1l3 Kiaa0987
identifier	Q9WV92
isSequenceChanged	false
keyword	Acetylation Actin-binding Alternative splicing Apoptosis Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane Phosphoprotein Reference proteome Tumor suppressor
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	Epb41l3
otherIdentifier	10446553 115369_at 117011_at 117012_g_at 130667_at 13823 1419062_at 1426010_a_at 1440595_at 17339313 4321417 4341888 4382353 4389904 4420850 4450004 4451091 4466141 4471436 4472679 4502010 4503395 4507915 4517169 4530833 4538210 4602898 4602963 4631480 4642486 4700971 4756275 4775287 4799509 4805701 4828663 4828711 4866829 4875206 4876403 4906628 4924538 4925252 5000482 5025749 5043015 5052572 5076503 5120357 5126528 5152852 5169699 5178505 5184271 5225515 5246817 5267429 5306712 5320560 5413516 5430026 5478650 5516207 5517310 5529390 5531172 5583980 5594301 5602592 5610844 5611987 A_51_P315411 A_55_P1960097 A_55_P2732131 A_55_P2744444 GE1548081 GE36599 GO:0002175 GO:0003779 GO:0005198 GO:0005200 GO:0005515 GO:0005737 GO:0005815 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005929 GO:0006915 GO:0007010 GO:0008092 GO:0008360 GO:0014069 GO:0016020 GO:0030054 GO:0030673 GO:0030865 GO:0030866 GO:0030913 GO:0031032 GO:0033270 GO:0034330 GO:0036064 GO:0043217 GO:0043226 GO:0044224 GO:0048812 GO:0060090 GO:0061024 GO:0061564 GO:0070161 GO:0071205 GO:0072659 GO:0106006 GO:1990227 ILMN_1242244 ILMN_1244272 ILMN_1254193 ILMN_2555027 ILMN_2618996 ILMN_2742833 mMC023565
physicalEntity	[EntityWithAccessionedSequence:R-MMU-9662959] Epb41l3 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-6797563] Epb41l3 [cytosol] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12670621] UCSC:Q9WV92 Epb41l3 [ReferenceDNASequence:12025574] NCBI Gene:13823 Epb41l3 [ReferenceDNASequence:11941481] Monarch:13823 Epb41l3 [ReferenceDNASequence:11855341] KEGG:mmu:13823 Epb41l3 [ReferenceDNASequence:11311692] BioGPS Gene:13823 Epb41l3
referenceTranscript	[ReferenceRNASequence:12494517] RefSeq:NM_013813.2 Epb41l3 [ReferenceRNASequence:12494512] RefSeq:XM_030249489.1 Epb41l3 [ReferenceRNASequence:12494511] RefSeq:NM_001424759.1 Epb41l3 [ReferenceRNASequence:12494514] RefSeq:XM_030249487.2 Epb41l3 [ReferenceRNASequence:12494513] RefSeq:NM_001355736.1 Epb41l3 [ReferenceRNASequence:12494516] RefSeq:XM_030249494.1 Epb41l3 [ReferenceRNASequence:12494515] RefSeq:XM_030249483.1 Epb41l3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	E41L3_MOUSE Q69ZT8 Q9R102
sequenceLength	929
species	[Species:48892] Mus musculus
stId	uniprot:Q9WV92
url	http://purl.uniprot.org/uniprot/Q9WV92

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