UniProt:Q9W0G1 Ptp61F

chain
  • chain:1-548
checksum C6AF630E2DE3F11C
comment
  • FUNCTION Non-receptor protein tyrosine phosphatase (PubMed:8463208). Required for maintaining dock/dreadlocks in its non-phosphorylated state (PubMed:12014990). Negative regulator of InR/insulin-like receptor signaling through dephosphorylation of tyrosines when recruited by dock/dreadlocks (PubMed:21707536).CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateSUBUNIT Interacts (via C-terminus) with dock/dreadlocks; this interaction is independent of insulin stimulation and is required for dephosphorylation of the insulin-like receptor InR.SUBCELLULAR LOCATION Associates with the membranes of the reticular network and the mitochondria.SUBCELLULAR LOCATION Detected in embryonic protein extracts (at protein level) (PubMed:8663600). Expressed during oogenesis and embryogenesis (PubMed:9256342). Expressed at low levels in the central nervous system of stage 14 embryos (PubMed:8663600). High levels of expression in 0-12 hour old embryos, pupae and adults with very low levels late in embryogenesis and in larvae (PubMed:8663600).DEVELOPMENTAL STAGE Accumulates in 16 segmentally repeated stripes in the ectoderm during germband extension (PubMed:9256342). These stripes are flanked by, and adjacent to, the domains of engrailed and wingless gene expression in the anterior/posterior axis (PubMed:9256342). In stage 10 embryos, isoform A colocalizes with the area lateral to the denticle belts that will give rise to naked cuticle (PubMed:9256342). Also expressed later in the central nervous system of embryos (PubMed:9256342).DEVELOPMENTAL STAGE Expressed in the mesoderm and neuroblast layer during germband extension and later in the gut epithelia.DOMAIN Contains 5 Potential PXXP motifs that may mediate interaction with the SH3 domains of dock/dreadlocks.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
created [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference
databaseName UniProt
dbId 415769
description
  • recommendedName: Tyrosine-protein phosphatase non-receptor type 61F ecNumber evidence="4 8 12"3.1.3.48 alternativeName: dPTP61F
displayName UniProt:Q9W0G1 Ptp61F
geneName
  • Ptp61F
  • PTP1B
  • CG9181
identifier Q9W0G1
isSequenceChanged false
keyword
  • Alternative splicing
  • Cytoplasm
  • Hydrolase
  • Membrane
  • Nucleus
  • Phosphoprotein
  • Protein phosphatase
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • Ptp61F
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PTP61_DROME
  • Q27932
  • Q8SZY3
  • Q9W0G2
sequenceLength 548
species [Species:56210] Drosophila melanogaster
stId uniprot:Q9W0G1
url http://purl.uniprot.org/uniprot/Q9W0G1
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