Reactome | UniProt:Q9VA38 wts

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UniProt:Q9VA38 wts Show undefined attributes

chain	chain:1-1105
checksum	7D09D7AA9BA1A856
comment	FUNCTION Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Inhibits nuclear localization of Yki. Regulates salivary gland degradation in a PI3K-dependent manner and Yki- and Sd-independent, mechanism.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Interacts with yki. Interacts with jub.INTERACTION Colocalizes with mats and cyclin E at the centrosome.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
created	[InstanceEdit:390104] Williams, MG, 2009-01-23 09:54:10
crossReference	[DatabaseIdentifier:12424716] RefSeq:NP_733403.1 [DatabaseIdentifier:12250623] PRO:Q9VA38 [DatabaseIdentifier:11776321] FlyBase:FBgn0011739 [DatabaseIdentifier:11730110] ENSEMBL:FBtr0085720 [DatabaseIdentifier:11607411] ENSEMBL:FBpp0085082 [DatabaseIdentifier:11498215] ENSEMBL:FBgn0011739
databaseName	UniProt
dbId	390076
description	recommendedName: Serine/threonine-protein kinase Warts ecNumber: 2.7.11.1
displayName	UniProt:Q9VA38 wts
geneName	wts CG12072
identifier	Q9VA38
isSequenceChanged	false
keyword	ATP-binding Cytoplasm Cytoskeleton Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Tumor suppressor
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	wts
otherIdentifier	143684_at 1635182_at 43651 GO:0000082 GO:0000166 GO:0001708 GO:0003824 GO:0004672 GO:0004674 GO:0004690 GO:0005515 GO:0005524 GO:0005737 GO:0005813 GO:0005815 GO:0005829 GO:0005856 GO:0005911 GO:0005912 GO:0006468 GO:0007298 GO:0007406 GO:0007423 GO:0007424 GO:0007444 GO:0007446 GO:0008285 GO:0008360 GO:0009653 GO:0009966 GO:0010212 GO:0016301 GO:0016740 GO:0022604 GO:0030154 GO:0030855 GO:0035329 GO:0042308 GO:0042771 GO:0043065 GO:0045177 GO:0045463 GO:0045464 GO:0045571 GO:0046620 GO:0046872 GO:0048666 GO:0048814 GO:0048856 GO:0048870 GO:0051093 GO:0060253 GO:0071944 GO:0072089 GO:0090090 GO:0106037 GO:0106310 GO:0140096 GO:1900181 GO:1904504
physicalEntity	[EntityWithAccessionedSequence:R-DME-390037] WTS [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-390056] Phospho WTS [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-390013] Phospho (2 sites) WTS [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-2028565] phospho-p-S872,T1041-LATS2 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-2028551] phospho-p-S909,T1079-LATS1 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-2028562] LATS1 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-2028580] LATS2 [cytosol] - Drosophila melanogaster
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12755141] UCSC:Q9VA38 wts [ReferenceDNASequence:12077609] NCBI Gene:43651 wts [ReferenceDNASequence:11993516] Monarch:43651 wts [ReferenceDNASequence:11902444] KEGG:dme:Dmel_CG12072 wts [ReferenceDNASequence:11418974] CTD Gene:43651 wts [ReferenceDNASequence:11363727] BioGPS Gene:43651 wts
referenceTranscript	[ReferenceRNASequence:12606289] RefSeq:NM_170524.2 wts
schemaClass	ReferenceGeneProduct
secondaryIdentifier	WARTS_DROME
sequenceLength	1105
species	[Species:56210] Drosophila melanogaster
stId	uniprot:Q9VA38
url	http://purl.uniprot.org/uniprot/Q9VA38

Referrals

(interactor)	[UndirectedInteraction:11137307] UniProt:Q9VA38 <-> UniProt:P49657 (IntAct) [UndirectedInteraction:11137305] UniProt:Q9VA38 <-> UniProt:d (IntAct) [UndirectedInteraction:11137301] UniProt:Q9VA38 <-> UniProt:Q9VR53 (IntAct) [UndirectedInteraction:11137299] UniProt:Q9VA38 <-> UniProt:Q8T0S6 (IntAct) [UndirectedInteraction:11137297] UniProt:Q9VA38 <-> UniProt:Q24564 (IntAct) [UndirectedInteraction:11131479] UniProt:Q9N675 <-> UniProt:Q9VA38 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-DME-390037] WTS [cytosol] [EntityWithAccessionedSequence:R-DME-390056] Phospho WTS [cytosol] [EntityWithAccessionedSequence:R-DME-390013] Phospho (2 sites) WTS [cytosol] [EntityWithAccessionedSequence:R-DME-2028565] phospho-p-S872,T1041-LATS2 [cytosol] [EntityWithAccessionedSequence:R-DME-2028551] phospho-p-S909,T1079-LATS1 [cytosol] [EntityWithAccessionedSequence:R-DME-2028562] LATS1 [cytosol] [EntityWithAccessionedSequence:R-DME-2028580] LATS2 [cytosol]
(referenceSequence)	[ModifiedResidue:390075] phosphorylated residue at unknown position [ModifiedResidue:10868730] O-phospho-L-threonine at 1041 (in Homo sapiens) [ModifiedResidue:10868729] O-phospho-L-serine at 872 (in Homo sapiens) [ModifiedResidue:10868726] O-phospho-L-threonine at 1079 (in Homo sapiens) [ModifiedResidue:10868725] O-phospho-L-serine at 909 (in Homo sapiens)