Reactome | UniProt:Q9V407 Axn

Schema > ReferenceGeneProduct > Entries

UniProt:Q9V407 Axn Show undefined attributes

chain	chain:1-745
checksum	31A502528CEE84BA
comment	FUNCTION Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).SUBUNIT Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.SUBCELLULAR LOCATION Ubiquitously expressed throughout the development.
crossReference	[DatabaseIdentifier:12411876] RefSeq:NP_733336.1 [DatabaseIdentifier:12411875] RefSeq:NP_733337.1 [DatabaseIdentifier:12244361] PRO:Q9V407 [DatabaseIdentifier:11774412] FlyBase:FBgn0026597 [DatabaseIdentifier:11721379] ENSEMBL:FBtr0085553 [DatabaseIdentifier:11721378] ENSEMBL:FBtr0085555 [DatabaseIdentifier:11598680] ENSEMBL:FBpp0084921 [DatabaseIdentifier:11598679] ENSEMBL:FBpp0084919 [DatabaseIdentifier:11491789] ENSEMBL:FBgn0026597
databaseName	UniProt
dbId	85721
description	recommendedName: Axin alternativeName: Axis inhibition protein alternativeName: d-Axin shortName: dAxin
displayName	UniProt:Q9V407 Axn
geneName	Axn CG7926
identifier	Q9V407
isSequenceChanged	false
keyword	Cytoplasm Developmental protein Phosphoprotein Reference proteome Wnt signaling pathway
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	Axn
otherIdentifier	154838_at 1632134_s_at 43565 GO:0005102 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0005977 GO:0007367 GO:0007450 GO:0007455 GO:0007507 GO:0008013 GO:0008587 GO:0016055 GO:0019901 GO:0022414 GO:0030707 GO:0030877 GO:0031625 GO:0032436 GO:0035019 GO:0035293 GO:0042594 GO:0048468 GO:0048477 GO:0048856 GO:0060070 GO:0060090 GO:0090090 GO:1900117 GO:1990909
physicalEntity	[EntityWithAccessionedSequence:R-DME-206017] AXN [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-206136] Phospho AXN [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-206169] Phospho (3 sites) AXN [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-4641131] Axn [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-4641133] Axn [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-3640821] Axn [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-3640841] phospho-Axn [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-3640842] phospho-Axn [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-3640859] phospho-Axn [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-3640864] phospho-Axn [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-206040] phospho-Axn [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-195249] Axn [cytosol] - Drosophila melanogaster
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12750445] UCSC:Q9V407 Axn [ReferenceDNASequence:12071126] NCBI Gene:43565 Axn [ReferenceDNASequence:11987033] Monarch:43565 Axn [ReferenceDNASequence:11896604] KEGG:dme:Dmel_CG7926 Axn [ReferenceDNASequence:11412396] CTD Gene:43565 Axn [ReferenceDNASequence:11357244] BioGPS Gene:43565 Axn
referenceTranscript	[ReferenceRNASequence:12593559] RefSeq:NM_170457.3 Axn [ReferenceRNASequence:12593560] RefSeq:NM_170458.2 Axn
schemaClass	ReferenceGeneProduct
secondaryIdentifier	AXN_DROME Q9XYC1
sequenceLength	745
species	[Species:56210] Drosophila melanogaster
stId	uniprot:Q9V407
url	http://purl.uniprot.org/uniprot/Q9V407

Referrals

(interactor)	[UndirectedInteraction:11192085] UniProt:Q9V407 <-> UniProt:P18824 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-DME-206017] AXN [cytosol] [EntityWithAccessionedSequence:R-DME-206136] Phospho AXN [cytosol] [EntityWithAccessionedSequence:R-DME-206169] Phospho (3 sites) AXN [cytosol] [EntityWithAccessionedSequence:R-DME-4641131] Axn [cytosol] [EntityWithAccessionedSequence:R-DME-4641133] Axn [cytosol] [EntityWithAccessionedSequence:R-DME-3640821] Axn [cytosol] [EntityWithAccessionedSequence:R-DME-3640841] phospho-Axn [cytosol] [EntityWithAccessionedSequence:R-DME-3640842] phospho-Axn [cytosol] [EntityWithAccessionedSequence:R-DME-3640859] phospho-Axn [cytosol] [EntityWithAccessionedSequence:R-DME-3640864] phospho-Axn [cytosol] [EntityWithAccessionedSequence:R-DME-206040] phospho-Axn [cytosol] [EntityWithAccessionedSequence:R-DME-195249] Axn [cytosol]
(referenceSequence)	[ModifiedResidue:205854] O-phospho-L-serine at 529 [ModifiedResidue:206043] O-phospho-L-serine at 522 [ModifiedResidue:205765] O-phospho-L-threonine at 517 [GroupModifiedResidue:10875461] ubiquitinylated lysine (K48polyUb [cytosol]) at 505 (in Homo sapiens) [GroupModifiedResidue:10874058] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position [ModifiedResidue:10874031] adenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position [ModifiedResidue:10842671] O-phospho-L-threonine at 481 (in Homo sapiens) [ModifiedResidue:10842672] O-phospho-L-serine at 486 (in Homo sapiens) [ModifiedResidue:10842673] O-phospho-L-serine at 493 (in Homo sapiens)

Cite Us!