UniProt:Q9UPT9 USP22

chain
  • chain:1-525
checksum D18BFE84BE8E5915
comment
  • FUNCTION Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator (PubMed:18206972, PubMed:18206973, PubMed:18469533). Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Facilitates cell-cycle progression by stabilizing CCNB1 and antagonizing its proteasome-mediated degradation in a cell cycle-specific manner (PubMed:27030811). Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation through deacetylase SIRT1 stabilization (PubMed:22542455). Plays multiple roles in immunity and inflammation. Participates in antiviral response by deubiquitinating the importin KPNA2, leading to IRF3 nuclear translocation and subsequent type I interferon production (PubMed:32130408). Acts as a central regulator of type III IFN signaling by negatively regulating STING1 activation and ubiquitination (PubMed:35933402). Inhibits NLRP3 inflammasome activation by promoting NLRP3 degradation through ATG5-dependent autophagy (By similarity). Deubiquitinates CD274 to induce its stabilization and thereby participates in maintenance of immune tolerance to self (PubMed:31399419). Controls necroptotic cell death by regulating RIPK3 phosphorylation and ubiquitination (PubMed:33369872). During bacterial infection, promotes pro-inflammatory response by targeting TRAF6 and removing its 'Lys-48'-linked polyubiquitination (By similarity).CATALYTIC ACTIVITY Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).SUBUNIT Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination (PubMed:18206972, PubMed:27601583). Interacts directly with ATXN7L3; leading to its recruitment to the SAGA complex (PubMed:18206972). Interacts with ATXN7L3 and weakly with ATXN7L3B (PubMed:27601583). Interacts with MED1 (By similarity).INTERACTION Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.PTM Phosphorylated in G2/M phase, but not in G1 phase by CDK1.PTM Ubiquitinated and subsequently degraded in a CDC20-dependent manner.SIMILARITY Belongs to the peptidase C19 family. UBP8 subfamily.
crossReference
databaseName UniProt
dbId 66858
description
  • recommendedName: Ubiquitin carboxyl-terminal hydrolase 22 ecNumber evidence="9 12 13 14"3.4.19.12 alternativeName: Deubiquitinating enzyme 22 alternativeName: Ubiquitin thioesterase 22 alternativeName: Ubiquitin-specific-processing protease 22
displayName UniProt:Q9UPT9 USP22
geneName
  • USP22
  • KIAA1063
  • USP3L
identifier Q9UPT9
isSequenceChanged false
keyword
  • Acetylation
  • Activator
  • Alternative splicing
  • Cell cycle
  • Chromatin regulator
  • Cytoplasm
  • Hydrolase
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Protease
  • Proteomics identification
  • Reference proteome
  • Thiol protease
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • USP22
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • UBP22_HUMAN
  • A0JNS3
  • Q2NLE2
  • Q6MZY4
  • Q8TBS8
  • Q96IW5
sequenceLength 525
species [Species:48887] Homo sapiens
stId uniprot:Q9UPT9
url http://purl.uniprot.org/uniprot/Q9UPT9
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