FUNCTION Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity).SUBUNIT The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).INTERACTION Translocates, as a preformed complex with EXOC3/SEC6 and EXOC4/SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214).ALTERNATIVE PRODUCTS Abundant in the ventricular zone, the outer subventricular zone and the cortical plate of the fetal cortex.DOMAIN The N-terminus is involved in SEC8 and ARHQ binding.DOMAIN The C-terminus is required for translocation to the plasma membrane.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be due to intron retention.SIMILARITY Belongs to the EXO70 family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.
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