Reactome | UniProt:Q9UNX4 WDR3

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UniProt:Q9UNX4 WDR3 Show undefined attributes

chain	chain:1-943
checksum	316A151738D91AD7
comment	FUNCTION Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.SUBUNIT Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.SUBCELLULAR LOCATION Ubiquitous.SIMILARITY Belongs to the WD repeat WDR3/UTP12 family.
crossReference	[DatabaseIdentifier:12403871] RefSeq:NP_006775.1 [DatabaseIdentifier:12282645] Pharos - Targets:Q9UNX4 [DatabaseIdentifier:12240617] PRO:Q9UNX4 [DatabaseIdentifier:12140101] PDB:7MQA [DatabaseIdentifier:12140946] PDB:7MQ9 [DatabaseIdentifier:12140947] PDB:7MQ8 [DatabaseIdentifier:12122323] OpenTargets:ENSG00000065183 [DatabaseIdentifier:11837825] HPA:ENSG00000065183-WDR3 [DatabaseIdentifier:11800240] GlyGen:Q9UNX4 [DatabaseIdentifier:11784732] GeneCards:WDR3 [DatabaseIdentifier:11715805] ENSEMBL:ENST00000349139 [DatabaseIdentifier:11593106] ENSEMBL:ENSP00000308179 [DatabaseIdentifier:11487986] ENSEMBL:ENSG00000065183
databaseName	UniProt
dbId	67320
description	recommendedName: WD repeat-containing protein 3
displayName	UniProt:Q9UNX4 WDR3
geneName	WDR3
identifier	Q9UNX4
isSequenceChanged	false
keyword	3D-structure Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation WD repeat
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	WDR3
otherIdentifier	10885 11742734_s_at 11751592_a_at 1557593_PM_at 1557593_at 16669288 218882_PM_s_at 218882_s_at 2354077 2354079 2354081 2354083 2354084 2354085 2354088 2354089 2354090 2354091 2354092 2354093 2354094 2354095 2354096 2354097 2354098 2354100 2354101 2354102 2354103 2354104 2354106 2354108 2354109 2354110 2354111 2354112 2354113 2354114 2354115 2354116 2354118 2354119 2354120 2354121 2354123 2354124 2354126 2354127 2354128 2354129 2354130 2354131 2354133 2354134 2354135 2354137 2354139 2354141 64096_at 7904364 80919_at A_14_P201561 A_23_P23318 A_24_P122524 A_33_P3211633 GE58423 GO:0003723 GO:0005515 GO:0005634 GO:0005654 GO:0005730 GO:0030490 GO:0030515 GO:0031965 GO:0032040 GO:0034388 GO:0042274 HMNXSV003020407 Hs2.87771.1.S1_3p_at Hs2.87771.1.S1_3p_s_at ILMN_1711254 PH_hs_0022987 TC01001033.hg TC01004662.hg g5803220_3p_a_at p28225
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6790724] WDR3 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12746846] UCSC:Q9UNX4 WDR3 [ReferenceDNASequence:12107940] OMIM:604737 WDR3 [ReferenceDNASequence:12067146] NCBI Gene:10885 WDR3 [ReferenceDNASequence:11983053] Monarch:10885 WDR3 [ReferenceDNASequence:11892911] KEGG:hsa:10885 WDR3 [ReferenceDNASequence:11816357] HGNC:12755 WDR3 [ReferenceDNASequence:11438354] dbSNP Gene:10885 WDR3 [ReferenceDNASequence:11408833] CTD Gene:10885 WDR3 [ReferenceDNASequence:11401090] COSMIC - genes:WDR3 WDR3 [ReferenceDNASequence:11353264] BioGPS Gene:10885 WDR3 [ReferenceDNASequence:ensembl:ENSG00000065183] ENSEMBL:ENSG00000065183 WDR3
referenceTranscript	[ReferenceRNASequence:12585591] RefSeq:NM_006784.3 WDR3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	WDR3_HUMAN
sequenceLength	943
species	[Species:48887] Homo sapiens
stId	uniprot:Q9UNX4
url	http://purl.uniprot.org/uniprot/Q9UNX4

Referrals

(interactor)	[UndirectedInteraction:11283151] UniProt:P06748 <-> UniProt:Q9UNX4 (IntAct) [UndirectedInteraction:11251897] UniProt:P0DTC9 <-> UniProt:Q9UNX4 (IntAct) [UndirectedInteraction:11222389] UniProt:Q99547 <-> UniProt:Q9UNX4 (IntAct) [UndirectedInteraction:11180625] UniProt:Q9NQT4 <-> UniProt:Q9UNX4 (IntAct) [UndirectedInteraction:11159951] UniProt:O43159 <-> UniProt:Q9UNX4 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6790724] WDR3 [nucleoplasm]