UniProt:Q9UNQ2 DIMT1

chain
  • chain:1-313
checksum 306B9D4A4F9494A6
comment
  • FUNCTION Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).CATALYTIC ACTIVITY adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)SUBUNIT Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.SUBCELLULAR LOCATION Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.
crossReference
databaseName UniProt
dbId 72305
description
  • recommendedName: Dimethyladenosine transferase ecNumber evidence="4"2.1.1.183 alternativeName: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase alternativeName: 18S rRNA dimethylase alternativeName: DIM1 dimethyladenosine transferase 1 homolog alternativeName: DIM1 dimethyladenosine transferase 1-like alternativeName: S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
displayName UniProt:Q9UNQ2 DIMT1
geneName
  • DIMT1
  • DIMT1L
  • HUSSY-05
identifier Q9UNQ2
isSequenceChanged false
keyword
  • 3D-structure
  • Methyltransferase
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • RNA-binding
  • rRNA processing
  • S-adenosyl-L-methionine
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • DIMT1
otherIdentifier
  • 11743593_at
  • 11745980_a_at
  • 11748536_a_at
  • 11761284_at
  • 16996645
  • 204405_PM_x_at
  • 204405_x_at
  • 210801_PM_at
  • 210801_at
  • 210802_PM_s_at
  • 210802_s_at
  • 217106_PM_x_at
  • 217106_x_at
  • 27292
  • 2859185
  • 2859186
  • 2859192
  • 2859194
  • 2859196
  • 2859197
  • 2859198
  • 2859199
  • 2859201
  • 2859202
  • 2859203
  • 2859204
  • 2859205
  • 2859206
  • 2859207
  • 2859208
  • 2859209
  • 2859210
  • 2859211
  • 2859212
  • 2859213
  • 2859214
  • 2859215
  • 2859216
  • 2859218
  • 2859220
  • 2859221
  • 2859222
  • 2859223
  • 2859224
  • 2859225
  • 2859226
  • 2859227
  • 39883_at
  • 39884_g_at
  • 8112312
  • A_23_P58529
  • A_24_P266035
  • A_24_P266037
  • GE58595
  • GO:0000154
  • GO:0000179
  • GO:0003723
  • GO:0003824
  • GO:0005634
  • GO:0005654
  • GO:0005730
  • GO:0005829
  • GO:0006364
  • GO:0008168
  • GO:0016740
  • GO:0031167
  • GO:0032040
  • GO:0032259
  • GO:0042274
  • GO:0052909
  • GO:0140098
  • GO:2000234
  • HMNXSV003024728
  • Hs.125819.4.A1_3p_a_at
  • ILMN_1803312
  • PH_hs_0007126
  • TC05001401.hg
  • g12803982_3p_at
  • g7657197_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DIM1_HUMAN
  • O76025
  • Q9BU77
  • Q9UES1
sequenceLength 313
species [Species:48887] Homo sapiens
stId uniprot:Q9UNQ2
url http://purl.uniprot.org/uniprot/Q9UNQ2
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