FUNCTION Reversible hydration of carbon dioxide.CATALYTIC ACTIVITY hydrogencarbonate + H(+) = CO2 + H2OCOFACTOR Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).BIOPHYSICOCHEMICAL PROPERTIES High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.SIMILARITY Belongs to the alpha-carbonic anhydrase family.
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