Reactome | UniProt:Q9ULL4 PLXNB3

Schema > ReferenceGeneProduct > Entries

UniProt:Q9ULL4 PLXNB3 Show undefined attributes

chain	signal peptide:1-44 chain:45-1909
checksum	11753CD58C7AC226
comment	FUNCTION Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.SUBUNIT Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain).INTERACTION Colocalizes with RIT2/RIN at the plasma membrane.ALTERNATIVE PRODUCTS Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines.SIMILARITY Belongs to the plexin family.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference	[DatabaseIdentifier:12406990] RefSeq:NP_005384.2 [DatabaseIdentifier:12406989] RefSeq:NP_001156729.1 [DatabaseIdentifier:12283605] Pharos - Targets:Q9ULL4 [DatabaseIdentifier:12242355] PRO:Q9ULL4 [DatabaseIdentifier:12123286] OpenTargets:ENSG00000198753 [DatabaseIdentifier:11838773] HPA:ENSG00000198753-PLXNB3 [DatabaseIdentifier:11785688] GeneCards:PLXNB3 [DatabaseIdentifier:11718124] ENSEMBL:ENST00000361971 [DatabaseIdentifier:11718123] ENSEMBL:ENST00000538966 [DatabaseIdentifier:11595424] ENSEMBL:ENSP00000355378 [DatabaseIdentifier:11595425] ENSEMBL:ENSP00000442736 [DatabaseIdentifier:11489459] ENSEMBL:ENSG00000198753
databaseName	UniProt
dbId	152660
description	recommendedName: Plexin-B3
displayName	UniProt:Q9ULL4 PLXNB3
geneName	PLXNB3 KIAA1206 PLXN6
identifier	Q9ULL4
isSequenceChanged	false
keyword	Alternative splicing Cell membrane Disulfide bond Glycoprotein Membrane Neurogenesis Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PLXNB3
otherIdentifier	11730518_a_at 11750114_a_at 11750115_x_at 11750761_x_at 11753364_a_at 17108113 205957_PM_at 205957_at 39214_at 3995886 3995887 3995888 3995889 3995890 3995891 3995892 3995893 3995894 3995895 3995896 3995898 3995899 3995900 3995901 3995902 3995903 3995904 3995906 3995907 3995908 3995909 3995910 3995911 3995912 3995913 3995914 3995915 3995917 3995918 3995919 3995920 3995921 3995922 3995925 3995926 3995927 3995928 3995929 3995930 3995931 3995932 3995933 3995934 3995935 3995936 3995937 3995938 3995939 3995940 3995941 3995942 3995943 3995944 3995945 5365 8170716 A_23_P137168 A_33_P3413038 GE53825 GO:0001938 GO:0002116 GO:0005515 GO:0005886 GO:0007156 GO:0007162 GO:0007399 GO:0007416 GO:0008360 GO:0009986 GO:0010593 GO:0010976 GO:0016020 GO:0017154 GO:0019904 GO:0030336 GO:0034260 GO:0034330 GO:0048856 GO:0048870 GO:0050772 GO:0050918 GO:0051022 GO:0060326 GO:0071526 GO:0098631 GO:0098632 HMNXSV003025509 ILMN_1686313 PH_hs_0018538 TC0X002322.hg U52111_rna4_at g10864080_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-416675] PLXNB3 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12748125] UCSC:Q9ULL4 PLXNB3 [ReferenceDNASequence:12108821] OMIM:300214 PLXNB3 [ReferenceDNASequence:12068575] NCBI Gene:5365 PLXNB3 [ReferenceDNASequence:11984482] Monarch:5365 PLXNB3 [ReferenceDNASequence:11894225] KEGG:hsa:5365 PLXNB3 [ReferenceDNASequence:11817319] HGNC:9105 PLXNB3 [ReferenceDNASequence:11438657] dbSNP Gene:5365 PLXNB3 [ReferenceDNASequence:11410287] CTD Gene:5365 PLXNB3 [ReferenceDNASequence:11401352] COSMIC - genes:PLXNB3 PLXNB3 [ReferenceDNASequence:11354693] BioGPS Gene:5365 PLXNB3 [ReferenceDNASequence:ensembl:ENSG00000198753] ENSEMBL:ENSG00000198753 PLXNB3
referenceTranscript	[ReferenceRNASequence:12588685] RefSeq:NM_005393.2 PLXNB3 [ReferenceRNASequence:12588686] RefSeq:NM_001163257.2 PLXNB3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PLXB3_HUMAN B7Z3E6 F5H773 Q9HDA4
sequenceLength	1909
species	[Species:48887] Homo sapiens
stId	uniprot:Q9ULL4
url	http://purl.uniprot.org/uniprot/Q9ULL4

Referrals

(interactor)	[UndirectedInteraction:11143627] UniProt:Q9ULL4 <-> UniProt:P08581 (IntAct) [UndirectedInteraction:11143625] UniProt:Q9ULL4 <-> UniProt:Q04912 (IntAct) [UndirectedInteraction:11143623] UniProt:Q9ULL4 <-> UniProt:Q92854 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-416675] PLXNB3 [plasma membrane]