UniProt:Q9ULH1 ASAP1

chain
  • chain:1-1129
checksum 7F54B22015638D55
comment
  • FUNCTION Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879).ACTIVITY REGULATION Activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).SUBUNIT Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2 (By similarity). Interacts with CTTN. Interacts (via SH3 domain) with APC. Interacts with REPS2; the interaction is direct (PubMed:12149250). Forms a complex containing RAB11A, ASAP1, RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport (PubMed:25673879).INTERACTION Predominantly cytoplasmic. Partially membrane-associated. Localized to the Golgi, TGN and rhodopsin transport carriers (RTC) when interacting with RHO in photoreceptors (PubMed:25673879). Localized to RTC when interacting with RAB11A and RAB11FIP3 in photoreceptors (PubMed:25673879).ALTERNATIVE PRODUCTS The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors.PTM Phosphorylated on tyrosine residues by SRC.
crossReference
databaseName UniProt
dbId 88880
description
  • recommendedName: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 alternativeName: 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein alternativeName: ADP-ribosylation factor-directed GTPase-activating protein 1 shortName: ARF GTPase-activating protein 1 alternativeName: Development and differentiation-enhancing factor 1 shortName: DEF-1 shortName: Differentiation-enhancing factor 1 alternativeName: PIP2-dependent ARF1 GAP
displayName UniProt:Q9ULH1 ASAP1
geneName
  • ASAP1
  • DDEF1
  • KIAA1249
  • PAG2
identifier Q9ULH1
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • ANK repeat
  • Cilium biogenesis/degradation
  • Cytoplasm
  • Golgi apparatus
  • GTPase activation
  • Membrane
  • Metal-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • SH3 domain
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ASAP1
otherIdentifier
  • 11717281_a_at
  • 11717282_at
  • 11717283_a_at
  • 11755032_s_at
  • 17081162
  • 221039_PM_s_at
  • 221039_s_at
  • 224790_PM_at
  • 224790_at
  • 224791_PM_at
  • 224791_at
  • 224796_PM_at
  • 224796_at
  • 236533_PM_at
  • 236533_at
  • 3153427
  • 3153429
  • 3153430
  • 3153431
  • 3153432
  • 3153433
  • 3153434
  • 3153435
  • 3153438
  • 3153440
  • 3153444
  • 3153447
  • 3153453
  • 3153454
  • 3153468
  • 3153469
  • 3153471
  • 3153472
  • 3153473
  • 3153475
  • 3153476
  • 3153477
  • 3153478
  • 3153481
  • 3153482
  • 3153483
  • 3153485
  • 3153486
  • 3153487
  • 3153489
  • 3153503
  • 3153504
  • 3153505
  • 3153506
  • 3153507
  • 3153508
  • 3153514
  • 3153515
  • 3153527
  • 3153528
  • 3153529
  • 3153530
  • 3153531
  • 3153532
  • 3153535
  • 3153544
  • 3153545
  • 3153549
  • 3153556
  • 3153603
  • 3153614
  • 3153616
  • 3153617
  • 3153621
  • 3153622
  • 3153628
  • 3153629
  • 3153644
  • 48803_at
  • 50807
  • 60030_at
  • 69516_at
  • 8152867
  • A_21_P0005976
  • A_23_P216278
  • A_23_P44831
  • A_23_P71526
  • A_33_P3775007
  • GE53850
  • GE633089
  • GE82388
  • GO:0000139
  • GO:0002102
  • GO:0005096
  • GO:0005515
  • GO:0005737
  • GO:0005794
  • GO:0005829
  • GO:0005886
  • GO:0008270
  • GO:0016020
  • GO:0030030
  • GO:0032588
  • GO:0034451
  • GO:0043226
  • GO:0043547
  • GO:0044782
  • GO:0045296
  • GO:0046872
  • GO:0060271
  • GO:0061512
  • GO:0098772
  • GO:1903527
  • HMNXSV003040355
  • HMNXSV003043886
  • Hs.10669.1.S1_3p_at
  • Hs.10669.1.S2_3p_at
  • Hs.10669.1.S3_3p_at
  • Hs.199057.0.A1_3p_at
  • ILMN_1690963
  • ILMN_2233366
  • PH_hs_0024401
  • PH_hs_0036086
  • RNA147148|p0252_imsncRNA402
  • TC08001641.hg
  • TC08002532.hg
  • g8923867_3p_a_at
  • p24051
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ASAP1_HUMAN
  • B2RNV3
sequenceLength 1129
species [Species:48887] Homo sapiens
stId uniprot:Q9ULH1
url http://purl.uniprot.org/uniprot/Q9ULH1
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