UniProt:Q9UK32 RPS6KA6

chain
  • chain:1-745
checksum 5EC5AB2FA1C19DE8
comment
  • FUNCTION Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved cells. Does not require growth factor stimulation for significant kinase activity.SUBUNIT Forms a complex with MAPK3/ERK1 but not with MAPK9 or MAPK14 in serum-starved cells.INTERACTION Predominantly cytosolic.ALTERNATIVE PRODUCTS Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
crossReference
databaseName UniProt
dbId 57801
description
  • recommendedName: Ribosomal protein S6 kinase alpha-6 shortName: S6K-alpha-6 ecNumber: 2.7.11.1 alternativeName: 90 kDa ribosomal protein S6 kinase 6 shortName: p90-RSK 6 shortName: p90RSK6 alternativeName: Ribosomal S6 kinase 4 shortName: RSK-4 alternativeName: pp90RSK4
displayName UniProt:Q9UK32 RPS6KA6
geneName
  • RPS6KA6
  • RSK4
identifier Q9UK32
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • ATP-binding
  • Cytoplasm
  • Kinase
  • Magnesium
  • Metal-binding
  • Nucleotide-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Serine/threonine-protein kinase
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • RPS6KA6
otherIdentifier
  • 11734272_a_at
  • 17112439
  • 220738_PM_s_at
  • 220738_s_at
  • 228502_PM_at
  • 228502_at
  • 228503_PM_at
  • 228503_at
  • 27330
  • 4014026
  • 4014028
  • 4014030
  • 4014031
  • 4014032
  • 4014033
  • 4014034
  • 4014037
  • 4014038
  • 4014039
  • 4014041
  • 4014042
  • 4014043
  • 4014044
  • 4014045
  • 4014046
  • 4014049
  • 4014050
  • 4014051
  • 4014052
  • 4014053
  • 4014057
  • 4014058
  • 4014059
  • 4014060
  • 4014061
  • 4014062
  • 4014064
  • 4014066
  • 4014067
  • 4014068
  • 4014069
  • 4014070
  • 4014071
  • 50972_s_at
  • 53658_at
  • 77852_r_at
  • 8173825
  • A_23_P125596
  • A_32_P424932
  • GE481984
  • GE81934
  • GE85049
  • GO:0000166
  • GO:0000287
  • GO:0001650
  • GO:0003824
  • GO:0004672
  • GO:0004674
  • GO:0004711
  • GO:0005515
  • GO:0005524
  • GO:0005634
  • GO:0005654
  • GO:0005730
  • GO:0005737
  • GO:0005739
  • GO:0005829
  • GO:0006468
  • GO:0007165
  • GO:0007417
  • GO:0016301
  • GO:0016740
  • GO:0030330
  • GO:0035556
  • GO:0038202
  • GO:0045992
  • GO:0046872
  • GO:0048856
  • GO:0070373
  • GO:0106310
  • GO:0140096
  • GO:2000381
  • HMNXSV003015599
  • Hs.234478.0.S1_3p_at
  • Hs.234478.0.S2_3p_at
  • ILMN_1807968
  • ILMN_1843157
  • PH_hs_0012792
  • PH_hs_0024060
  • TC0X001186.hg
  • TC0X002141.hg
  • g7657525_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KS6A6_HUMAN
  • B2R854
  • B7ZL90
  • Q6FHX2
  • Q8WX28
  • Q9H4S6
sequenceLength 745
species [Species:48887] Homo sapiens
stId uniprot:Q9UK32
url http://purl.uniprot.org/uniprot/Q9UK32
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