UniProt:Q9UK22 FBXO2

chain
  • chain:1-296
checksum 5226F19E27D884AF
comment
  • FUNCTION Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).
crossReference
databaseName UniProt
dbId 54688
description
  • recommendedName: F-box only protein 2
displayName UniProt:Q9UK22 FBXO2
geneName
  • FBXO2
  • FBX2
identifier Q9UK22
isSequenceChanged false
keyword
  • Cytoplasm
  • Endoplasmic reticulum
  • Lectin
  • Membrane
  • Microsome
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation pathway
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • FBXO2
otherIdentifier
  • 11722234_x_at
  • 11722235_a_at
  • 11722236_at
  • 16681735
  • 219305_PM_x_at
  • 219305_x_at
  • 2396756
  • 2396759
  • 2396760
  • 2396761
  • 2396762
  • 2396763
  • 2396764
  • 2396765
  • 2396766
  • 2396767
  • 2396768
  • 2396770
  • 2396771
  • 2396773
  • 2396774
  • 2396776
  • 26232
  • 57811_at
  • 7912473
  • 86983_at
  • A_23_P45999
  • GE481447
  • GE81762
  • GE88178
  • GO:0001540
  • GO:0003824
  • GO:0004842
  • GO:0005515
  • GO:0005737
  • GO:0005783
  • GO:0005829
  • GO:0006508
  • GO:0006511
  • GO:0006516
  • GO:0008285
  • GO:0016020
  • GO:0016567
  • GO:0016740
  • GO:0019005
  • GO:0030163
  • GO:0030246
  • GO:0031146
  • GO:0031249
  • GO:0031396
  • GO:0036211
  • GO:0036503
  • GO:0043197
  • GO:0061630
  • GO:0098890
  • GO:0098978
  • GO:0099576
  • GO:0140096
  • GO:1901135
  • HMNXSV003052169
  • ILMN_1803211
  • PH_hs_0007951
  • PH_hs_0031749
  • TC01002199.hg
  • TC01005265.hg
  • g6912363_3p_at
  • p26578
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FBX2_HUMAN
  • B2R7K7
  • Q5TGY0
  • Q6FGJ7
  • Q8TB29
  • Q9UKC6
sequenceLength 296
species [Species:48887] Homo sapiens
stId uniprot:Q9UK22
url http://purl.uniprot.org/uniprot/Q9UK22

Referrals

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