Reactome | UniProt:Q9UJW0 DCTN4

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UniProt:Q9UJW0 DCTN4 Show undefined attributes

chain	initiator methionine:1 chain:2-460
checksum	2105D6C0A713B11D
comment	FUNCTION Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.SUBUNIT Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (By similarity). Interacts with ATP7B, but not ATP7A, in a copper-dependent manner (PubMed:16554302). Interacts with ANK2; this interaction is required for localization at costameres (By similarity). Interacts with N4BP2L1 (By similarity).INTERACTION Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (PubMed:10671518). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity).ALTERNATIVE PRODUCTS Belongs to the dynactin subunit 4 family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11486003] ENSEMBL:ENSG00000132912 [DatabaseIdentifier:11589689] ENSEMBL:ENSP00000411251 [DatabaseIdentifier:11589688] ENSEMBL:ENSP00000414906 [DatabaseIdentifier:11589687] ENSEMBL:ENSP00000416968 [DatabaseIdentifier:11712386] ENSEMBL:ENST00000424236 [DatabaseIdentifier:11712387] ENSEMBL:ENST00000447998 [DatabaseIdentifier:11712388] ENSEMBL:ENST00000446090 [DatabaseIdentifier:11782716] GeneCards:DCTN4 [DatabaseIdentifier:11798376] GlyGen:Q9UJW0 [DatabaseIdentifier:11835831] HPA:ENSG00000132912-DCTN4 [DatabaseIdentifier:12120293] OpenTargets:ENSG00000132912 [DatabaseIdentifier:12135550] Orphanet:DCTN4 [DatabaseIdentifier:12146948] PDB:9B7J [DatabaseIdentifier:12146949] PDB:9B85 [DatabaseIdentifier:12237661] PRO:Q9UJW0 [DatabaseIdentifier:12280630] Pharos - Targets:Q9UJW0 [DatabaseIdentifier:12398775] RefSeq:NP_057305.1 [DatabaseIdentifier:12398772] RefSeq:XP_047273217.1 [DatabaseIdentifier:12398771] RefSeq:NP_001129116.1 [DatabaseIdentifier:12398769] RefSeq:XP_054208692.1 [DatabaseIdentifier:12398773] RefSeq:XP_011535947.1 [DatabaseIdentifier:12398770] RefSeq:NP_001129115.1 [DatabaseIdentifier:12398774] RefSeq:XP_011535946.1
databaseName	UniProt
dbId	226618
description	recommendedName: Dynactin subunit 4 shortName: Dyn4 alternativeName: Dynactin subunit p62
displayName	UniProt:Q9UJW0 DCTN4
geneName	DCTN4
identifier	Q9UJW0
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Coiled coil Cytoplasm Cytoskeleton Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	DCTN4
otherIdentifier	11718742_s_at 11734569_a_at 11734570_s_at 11734571_x_at 11749838_a_at 11751475_a_at 17001718 218013_PM_x_at 218013_x_at 222488_PM_s_at 222488_s_at 231055_PM_at 231055_at 233490_PM_at 233490_at 2881550 2881552 2881553 2881555 2881556 2881557 2881558 2881559 2881560 2881561 2881563 2881564 2881565 2881569 2881571 2881572 2881573 2881574 2881575 2881576 2881577 2881579 2881580 2881581 2881582 2881583 2881584 2881585 2881586 3054395 43847_s_at 51164 65917_at 73429_at 77228_at 8115181 83502_at A_23_P251945 A_32_P122951 GE55433 GO:0000776 GO:0000922 GO:0001725 GO:0005515 GO:0005634 GO:0005737 GO:0005813 GO:0005815 GO:0005829 GO:0005856 GO:0005868 GO:0005869 GO:0005925 GO:0005938 GO:0030017 GO:0043226 HMNXSV003017364 Hs.180952.0.A2_3p_a_at Hs.180952.2.A1_3p_a_at Hs.263462.0.A1_3p_at PH_hs_0016236 TC05001943.hg g7705892_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2029070] DCTN4 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12745547] UCSC:Q9UJW0 DCTN4 [ReferenceDNASequence:ensembl:ENSG00000132912] ENSEMBL:ENSG00000132912 DCTN4 [ReferenceDNASequence:11351307] BioGPS Gene:51164 DCTN4 [ReferenceDNASequence:11400719] COSMIC - genes:DCTN4 DCTN4 [ReferenceDNASequence:11406175] CTD Gene:51164 DCTN4 [ReferenceDNASequence:11437923] dbSNP Gene:51164 DCTN4 [ReferenceDNASequence:11814324] HGNC:15518 DCTN4 [ReferenceDNASequence:11891076] KEGG:hsa:51164 DCTN4 [ReferenceDNASequence:11981096] Monarch:51164 DCTN4 [ReferenceDNASequence:12065189] NCBI Gene:51164 DCTN4 [ReferenceDNASequence:12106115] OMIM:614758 DCTN4
referenceTranscript	[ReferenceRNASequence:12580481] RefSeq:NM_001135644.2 DCTN4 [ReferenceRNASequence:12580479] RefSeq:XM_011537644.2 DCTN4 [ReferenceRNASequence:12580480] RefSeq:NM_001135643.2 DCTN4 [ReferenceRNASequence:12580483] RefSeq:XM_011537645.2 DCTN4 [ReferenceRNASequence:12580482] RefSeq:XM_047417261.1 DCTN4 [ReferenceRNASequence:12580478] RefSeq:XM_054352717.1 DCTN4 [ReferenceRNASequence:12580477] RefSeq:NM_016221.4 DCTN4
schemaClass	ReferenceGeneProduct
secondaryIdentifier	DCTN4_HUMAN B3KWW0 D3DQH0 E5RGT5 Q8TAN8
sequenceLength	460
species	[Species:48887] Homo sapiens
stId	uniprot:Q9UJW0
url	http://purl.uniprot.org/uniprot/Q9UJW0

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2029070] DCTN4 [cytosol]
(interactor)	[UndirectedInteraction:11148175] UniProt:P13569 <-> UniProt:Q9UJW0 (IntAct) [UndirectedInteraction:11197875] UniProt:Q08379 <-> UniProt:Q9UJW0 (IntAct) [UndirectedInteraction:11201409] UniProt:Q14203 <-> UniProt:Q9UJW0 (IntAct) [UndirectedInteraction:11227221] UniProt:P42858 <-> UniProt:Q9UJW0 (IntAct) [UndirectedInteraction:11241245] UniProt:P47756 <-> UniProt:Q9UJW0 (IntAct)