UniProt:Q9UIX4 KCNG1

chain
  • chain:1-513
checksum A002F1C0EF2FBDC5
comment
  • FUNCTION Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization (PubMed:19074135). Potassium channel subunit that does not form functional channels by itself (PubMed:19074135).SUBUNIT Heterotetramer with KCNB1 (Probable). Heterotetramer with KCNB2 (By similarity).SUBCELLULAR LOCATION Colocalizes with KCNB1 at the plasma membrane.ALTERNATIVE PRODUCTS Expressed in brain and placenta, and at much lower levels in kidney and pancreas (PubMed:9434767).DOMAIN The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.SIMILARITY Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily.
crossReference
databaseName UniProt
dbId 57913
description
  • recommendedName: fullName evidence="8"Voltage-gated potassium channel regulatory subunit KCNG1 alternativeName: Potassium voltage-gated channel subfamily G member 1 alternativeName: Voltage-gated potassium channel subunit Kv6.1 alternativeName: kH2
displayName UniProt:Q9UIX4 KCNG1
geneName
  • KCNG1
identifier Q9UIX4
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Ion channel
  • Ion transport
  • Membrane
  • Potassium
  • Potassium channel
  • Potassium transport
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
  • Transport
  • Voltage-gated channel
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • KCNG1
otherIdentifier
  • 11735788_a_at
  • 11761255_at
  • 16920299
  • 211053_PM_at
  • 211053_at
  • 214595_PM_at
  • 214595_at
  • 37498_at
  • 3755
  • 3909443
  • 3909444
  • 3909445
  • 3909446
  • 3909447
  • 3909448
  • 3909449
  • 3909450
  • 3909451
  • 3909452
  • 3909453
  • 3909454
  • 3909455
  • 3909456
  • 3909457
  • 3909459
  • 3909460
  • 3909461
  • 3909462
  • 3909463
  • 8067029
  • 8067033
  • A_23_P210581
  • A_24_P237117
  • A_33_P3362296
  • GE479898
  • GE56307
  • GO:0001508
  • GO:0005216
  • GO:0005249
  • GO:0005267
  • GO:0005515
  • GO:0005886
  • GO:0006811
  • GO:0006813
  • GO:0008076
  • GO:0015459
  • GO:0016020
  • GO:0034220
  • GO:0034702
  • GO:0043266
  • GO:0051260
  • GO:0055085
  • GO:0065003
  • GO:0071805
  • GO:0098772
  • GO:1901379
  • HMNXSV003028197
  • HMNXSV003039120
  • Hs.118695.0.S2_3p_at
  • Hs.118695.0.S2_3p_x_at
  • ILMN_1670833
  • ILMN_1673769
  • ILMN_2293363
  • PH_hs_0031572
  • TC20000941.hg
  • g13623518_3p_at
  • p33512
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KCNG1_HUMAN
  • A8K3S4
  • O43528
  • Q5JXL5
  • Q9BRC1
sequenceLength 513
species [Species:48887] Homo sapiens
stId uniprot:Q9UIX4
url http://purl.uniprot.org/uniprot/Q9UIX4
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