Reactome | UniProt:Q9UIQ6 LNPEP

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UniProt:Q9UIQ6 LNPEP Show undefined attributes

chain	chain:1-1025 chain:155-1025
checksum	F84C0EA9D48DC2C0
comment	FUNCTION Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.CATALYTIC ACTIVITY Release of an N-terminal amino acid, Cys-\|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.COFACTOR Binds 1 zinc ion per subunit.SUBUNIT Homodimer. Binds tankyrases 1 and 2.INTERACTION In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.SUBCELLULAR LOCATION During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.ALTERNATIVE PRODUCTS Experimental confirmation may be lacking for some isoforms.TISSUE SPECIFICITY Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.PTM The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.PTM N-glycosylated.SIMILARITY Belongs to the peptidase M1 family.
crossReference	[DatabaseIdentifier:12807283] ZINC - Metabolites:LCAP_HUMAN [DatabaseIdentifier:12814981] ZINC target:Q9UIQ6 [DatabaseIdentifier:12811649] ZINC - Substances:LCAP_HUMAN [DatabaseIdentifier:12809427] ZINC - Predictions - Purchasable:LCAP_HUMAN [DatabaseIdentifier:11486083] ENSEMBL:ENSG00000113441 [DatabaseIdentifier:11589822] ENSEMBL:ENSP00000379117 [DatabaseIdentifier:11589823] ENSEMBL:ENSP00000231368 [DatabaseIdentifier:11712521] ENSEMBL:ENST00000231368 [DatabaseIdentifier:11712522] ENSEMBL:ENST00000395770 [DatabaseIdentifier:11779881] Guide to Pharmacology - Targets:1570 [DatabaseIdentifier:11782783] GeneCards:LNPEP [DatabaseIdentifier:11798441] GlyGen:Q9UIQ6 [DatabaseIdentifier:11830305] HMDB Protein:HMDBP02475 [DatabaseIdentifier:11835896] HPA:ENSG00000113441-LNPEP [DatabaseIdentifier:11850709] IntEnz:3.4.11.3 [DatabaseIdentifier:12120359] OpenTargets:ENSG00000113441 [DatabaseIdentifier:12147790] PDB:7ZYF [DatabaseIdentifier:12147791] PDB:8P0I [DatabaseIdentifier:12147788] PDB:5C97 [DatabaseIdentifier:12147793] PDB:5MJ6 [DatabaseIdentifier:12147795] PDB:8CGP [DatabaseIdentifier:12147789] PDB:5JHQ [DatabaseIdentifier:12147794] PDB:6YDX [DatabaseIdentifier:12147785] PDB:4PJ6 [DatabaseIdentifier:12147786] PDB:4Z7I [DatabaseIdentifier:12147792] PDB:4P8Q [DatabaseIdentifier:12147787] PDB:8CGW [DatabaseIdentifier:12237798] PRO:Q9UIQ6 [DatabaseIdentifier:12280696] Pharos - Targets:Q9UIQ6 [DatabaseIdentifier:12399006] RefSeq:NP_005566.2 [DatabaseIdentifier:12399005] RefSeq:NP_787116.2 [DatabaseIdentifier:12803901] ZINC - Biogenic:LCAP_HUMAN
databaseName	UniProt
dbId	58435
description	recommendedName: Leucyl-cystinyl aminopeptidase shortName: Cystinyl aminopeptidase ecNumber: 3.4.11.3 alternativeName: Insulin-regulated membrane aminopeptidase alternativeName: Insulin-responsive aminopeptidase shortName: IRAP alternativeName: Oxytocinase shortName: OTase alternativeName: Placental leucine aminopeptidase shortName: P-LAP component recommendedName: Leucyl-cystinyl aminopeptidase, pregnancy serum form /component
displayName	UniProt:Q9UIQ6 LNPEP
geneName	LNPEP OTASE
identifier	Q9UIQ6
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Aminopeptidase Cell membrane Direct protein sequencing Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Phosphoprotein Protease Proteomics identification Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix Zinc
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	LNPEP
physicalEntity	[EntityWithAccessionedSequence:R-HSA-983098] LNPEP [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1236834] LNPEP [early endosome lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1445121] LNPEP [cytoplasmic vesicle membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000113441] ENSEMBL:ENSG00000113441 LNPEP [ReferenceDNASequence:11351406] BioGPS Gene:4012 LNPEP [ReferenceDNASequence:11400740] COSMIC - genes:LNPEP LNPEP [ReferenceDNASequence:11406280] CTD Gene:4012 LNPEP [ReferenceDNASequence:11437949] dbSNP Gene:4012 LNPEP [ReferenceDNASequence:11814391] HGNC:6656 LNPEP [ReferenceDNASequence:11891171] KEGG:hsa:4012 LNPEP [ReferenceDNASequence:11981195] Monarch:4012 LNPEP [ReferenceDNASequence:12065288] NCBI Gene:4012 LNPEP [ReferenceDNASequence:12106175] OMIM:151300 LNPEP [ReferenceDNASequence:12745585] UCSC:Q9UIQ6 LNPEP
referenceTranscript	[ReferenceRNASequence:12580711] RefSeq:NM_175920.4 LNPEP [ReferenceRNASequence:12580710] RefSeq:NM_005575.3 LNPEP
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LCAP_HUMAN O00769 Q15145 Q59H76 Q9TNQ2 Q9TNQ3 Q9UIQ7
sequenceLength	1025
species	[Species:48887] Homo sapiens
stId	uniprot:Q9UIQ6
url	http://purl.uniprot.org/uniprot/Q9UIQ6

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-983098] LNPEP [cytosol] [EntityWithAccessionedSequence:R-HSA-1236834] LNPEP [early endosome lumen] [EntityWithAccessionedSequence:R-HSA-1445121] LNPEP [cytoplasmic vesicle membrane]
(interactor)	[UndirectedInteraction:11264463] UniProt:P80370 <-> UniProt:Q9UIQ6 (IntAct) [UndirectedInteraction:11271727] UniProt:P17931 <-> UniProt:Q9UIQ6 (IntAct) [UndirectedInteraction:11299285] UniProt:P27824 <-> UniProt:Q9UIQ6 (IntAct)