UniProt:Q9UI95 MAD2L2

chain
  • chain:1-211
checksum 1DE6353EF7D650B9
comment
  • FUNCTION Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17296730, PubMed:17719540, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194, PubMed:23143872). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654).SUBUNIT Homooligomer (Probable). Heterodimer with REV3L (PubMed:10660610, PubMed:11485998, PubMed:23143872). This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context (PubMed:11485998). Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta (PubMed:24449906). Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7 (PubMed:29656893, PubMed:29789392). Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus (PubMed:29656893). Interacts with REV1 (PubMed:11485998, PubMed:20164194, PubMed:23143872). Interacts with ADAM9 (PubMed:10527948). Interacts with CHAMP1 (PubMed:21063390). Interacts with FZR1 (in complex with the anaphase promoting complex APC) (PubMed:11459825, PubMed:11459826). Interacts with CDC20; PubMed:11459825 could not detect the interaction (PubMed:11459826). Interacts with RAN (PubMed:19753112). Interacts with ELK1; the interaction is direct and recruits MAD2L2 to ELK1-specific promoters (PubMed:17296730). May interact with the JNK kinases MAPK8 and/or MAPK9 to stimulate ELK1 phosphorylation and transcriptional activity upon DNA damage (PubMed:17296730). Interacts with TCF7L2; prevents its binding to promoters and negatively modulates its transcriptional activity (PubMed:19443654). Interacts with YY1AP1 (PubMed:17541814). Interacts with S.flexneri protein ipaB; prevents the interaction of MAD2L2 with FZR1 and CDC20 resulting in an activation of the anaphase-promoting complex APC and a cell cycle arrest (PubMed:17719540). Interacts with PRCC; the interaction is direct (PubMed:11717438). Interacts with POGZ (PubMed:20850016). Interacts with ASTE1 (PubMed:34354233). Forms a quaternary complex with POLK, REV1 and REV3L, where REV3L-bound MAD2L2 and POLK are able to bind simultaneously to REV1 forming the stable translesion synthesis (TLS) machinery therefore bridging the inserter and extender polymerases (PubMed:23143872).INTERACTION Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.TISSUE SPECIFICITY Ubiquitously expressed.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference
databaseName UniProt
dbId 69809
description
  • recommendedName: Mitotic spindle assembly checkpoint protein MAD2B alternativeName: Mitotic arrest deficient 2-like protein 2 shortName: MAD2-like protein 2 alternativeName: REV7 homolog shortName: hREV7
displayName UniProt:Q9UI95 MAD2L2
geneName
  • MAD2L2
  • MAD2B
  • REV7
identifier Q9UI95
isSequenceChanged false
keyword
  • 3D-structure
  • Cell cycle
  • Cell division
  • Chromosome
  • Cytoplasm
  • Cytoskeleton
  • Disease variant
  • DNA damage
  • DNA repair
  • Fanconi anemia
  • Mitosis
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • MAD2L2
otherIdentifier
  • 10459
  • 11722434_a_at
  • 16681749
  • 223234_PM_at
  • 223234_at
  • 2396776
  • 2396778
  • 2396780
  • 2396782
  • 2396783
  • 2396784
  • 2396785
  • 2396786
  • 2396787
  • 2396788
  • 2396789
  • 2396790
  • 2396791
  • 2396792
  • 2396793
  • 2396794
  • 2396795
  • 2396796
  • 2396797
  • 2396798
  • 2396799
  • 2396800
  • 56235_at
  • 7912481
  • A_23_P23206
  • A_33_P3359250
  • A_33_P3359253
  • GE58399
  • GE85018
  • GO:0000122
  • GO:0000785
  • GO:0001558
  • GO:0002208
  • GO:0002376
  • GO:0003714
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005680
  • GO:0005694
  • GO:0005737
  • GO:0005819
  • GO:0005856
  • GO:0006281
  • GO:0006302
  • GO:0006355
  • GO:0006974
  • GO:0007015
  • GO:0007094
  • GO:0008432
  • GO:0010717
  • GO:0010719
  • GO:0010944
  • GO:0016035
  • GO:0032200
  • GO:0033138
  • GO:0035861
  • GO:0042177
  • GO:0042276
  • GO:0042772
  • GO:0043226
  • GO:0043247
  • GO:0045830
  • GO:0045893
  • GO:0051301
  • GO:0061629
  • GO:0090090
  • GO:1904667
  • GO:2000042
  • GO:2000048
  • GO:2001034
  • HMNXSV003002370
  • HMNXSV003029504
  • HMNXSV003054764
  • ILMN_1669550
  • PH_hs_0001706
  • TC01002200.hg
  • g6642734_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MD2L2_HUMAN
  • B3KNE3
  • Q5TGW7
  • Q9UNA7
  • Q9Y6I6
sequenceLength 211
species [Species:48887] Homo sapiens
stId uniprot:Q9UI95
url http://purl.uniprot.org/uniprot/Q9UI95

Referrals

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