Reactome | UniProt:Q9UHV7 MED13

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UniProt:Q9UHV7 MED13 Show undefined attributes

chain	chain:1-2174
checksum	0FA54C84FE2C91E2
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.INTERACTION Ubiquitous.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Mediator complex subunit 13 family.
crossReference	[DatabaseIdentifier:11487419] ENSEMBL:ENSG00000108510 [DatabaseIdentifier:11592238] ENSEMBL:ENSP00000380888 [DatabaseIdentifier:11714937] ENSEMBL:ENST00000397786 [DatabaseIdentifier:11784346] GeneCards:MED13 [DatabaseIdentifier:11799817] GlyGen:Q9UHV7 [DatabaseIdentifier:11837443] HPA:ENSG00000108510-MED13 [DatabaseIdentifier:12121938] OpenTargets:ENSG00000108510 [DatabaseIdentifier:12136496] Orphanet:MED13 [DatabaseIdentifier:12139979] PDB:8TRH [DatabaseIdentifier:12139978] PDB:8TQW [DatabaseIdentifier:12156735] PDB:8TQC [DatabaseIdentifier:12139984] PDB:8T9D [DatabaseIdentifier:12156736] PDB:8TQ2 [DatabaseIdentifier:12239942] PRO:Q9UHV7 [DatabaseIdentifier:12282262] Pharos - Targets:Q9UHV7 [DatabaseIdentifier:12402538] RefSeq:NP_005112.2
databaseName	UniProt
dbId	65530
description	recommendedName: fullName evidence="10"Mediator of RNA polymerase II transcription subunit 13 alternativeName: Activator-recruited cofactor 250 kDa component shortName: ARC250 alternativeName: Mediator complex subunit 13 alternativeName: Thyroid hormone receptor-associated protein 1 alternativeName: Thyroid hormone receptor-associated protein complex 240 kDa component shortName: Trap240 alternativeName: Vitamin D3 receptor-interacting protein complex component DRIP250 shortName: DRIP250
displayName	UniProt:Q9UHV7 MED13
geneName	MED13 ARC250 KIAA0593 THRAP1 TRAP240
identifier	Q9UHV7
isSequenceChanged	false
keyword	3D-structure Activator Direct protein sequencing Disease variant Intellectual disability Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	MED13
otherIdentifier	11739632_at 11739633_s_at 11739634_at 11739635_at 11757402_s_at 16847485 201986_PM_at 201986_at 201987_PM_at 201987_at 223780_PM_s_at 223780_s_at 244611_PM_at 244611_at 3765688 3765690 3765691 3765692 3765693 3765694 3765695 3765696 3765697 3765698 3765700 3765701 3765702 3765703 3765704 3765705 3765706 3765707 3765712 3765713 3765714 3765715 3765718 3765719 3765721 3765722 3765726 3765728 3765729 3765731 3765733 3765735 3765738 3765746 3765747 3765748 3765749 3765750 3765752 3765753 3765754 3765755 3765756 3765758 3765759 3765761 3765767 3765769 3765770 3765771 41625_at 48255_f_at 48256_r_at 52695_at 54447_at 54686_at 69595_at 8017312 9969 A_23_P27247 A_24_P17077 A_33_P3223759 GE81474 GO:0000122 GO:0003712 GO:0003713 GO:0005515 GO:0005634 GO:0005654 GO:0006355 GO:0006357 GO:0016020 GO:0016592 GO:0042632 GO:0042809 GO:0045893 GO:0045944 GO:0046966 GO:0060261 GO:0070328 GO:1990508 HMNXSV003011150 Hs.11861.0.A2_3p_at Hs.11861.0.A3_3p_at Hs.11861.0.A3_3p_x_at Hs.85481.0.A1_3p_at ILMN_1671067 ILMN_1806184 PH_hs_0025729 TC17001772.hg g7106831_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-212391] MED13 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12746335] UCSC:Q9UHV7 MED13 [ReferenceDNASequence:ensembl:ENSG00000108510] ENSEMBL:ENSG00000108510 MED13 [ReferenceDNASequence:11352686] BioGPS Gene:9969 MED13 [ReferenceDNASequence:11401006] COSMIC - genes:MED13 MED13 [ReferenceDNASequence:11408246] CTD Gene:9969 MED13 [ReferenceDNASequence:11438265] dbSNP Gene:9969 MED13 [ReferenceDNASequence:11815971] HGNC:22474 MED13 [ReferenceDNASequence:11892369] KEGG:hsa:9969 MED13 [ReferenceDNASequence:11982475] Monarch:9969 MED13 [ReferenceDNASequence:12066568] NCBI Gene:9969 MED13 [ReferenceDNASequence:12107591] OMIM:603808 MED13
referenceTranscript	[ReferenceRNASequence:12584269] RefSeq:NM_005121.3 MED13
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MED13_HUMAN B2RU05 O60334
sequenceLength	2174
species	[Species:48887] Homo sapiens
stId	uniprot:Q9UHV7
url	http://purl.uniprot.org/uniprot/Q9UHV7

Referrals

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[EntityWithAccessionedSequence:R-HSA-212391] MED13 [nucleoplasm]

(interactor)