Reactome | UniProt:Q9UHA4 LAMTOR3

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UniProt:Q9UHA4 LAMTOR3 Show undefined attributes

chain	chain:1-124
checksum	0A5196CF41D83D13
comment	FUNCTION As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:30181260). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).SUBUNIT Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 (PubMed:20381137, PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:29285400, PubMed:31601708, PubMed:32868926, PubMed:35338845, PubMed:36103527, PubMed:36697823). LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:20381137, PubMed:22980980). Interacts with LAMTOR1 and LAMTOR2; the interaction is direct (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability (PubMed:20381137, PubMed:32868926). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906, PubMed:32868926). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (PubMed:31672913, PubMed:31704029, PubMed:32868926). Interacts with MAP2K1/MEK1 and MAPK2 (By similarity). Interacts with MORG1 (By similarity).INTERACTION Recruited to lysosome and endosome membranes by LAMTOR1.ALTERNATIVE PRODUCTS Belongs to the LAMTOR3 family.
crossReference	[DatabaseIdentifier:12153915] PDB:7T3C [DatabaseIdentifier:12480165] RefSeq:NP_068805.1 [DatabaseIdentifier:12480166] RefSeq:NP_001230665.1 [DatabaseIdentifier:12292945] Pharos - Targets:Q9UHA4 [DatabaseIdentifier:12276019] PRO:Q9UHA4 [DatabaseIdentifier:12156120] PDB:1SKO [DatabaseIdentifier:12153910] PDB:6WJ3 [DatabaseIdentifier:12153906] PDB:6WJ2 [DatabaseIdentifier:12153905] PDB:6EHP [DatabaseIdentifier:12153911] PDB:7UXC [DatabaseIdentifier:12153904] PDB:5Y3A [DatabaseIdentifier:12156123] PDB:2ZL1 [DatabaseIdentifier:12153901] PDB:7UX2 [DatabaseIdentifier:12156125] PDB:3CPT [DatabaseIdentifier:12153919] PDB:8DHB [DatabaseIdentifier:12153916] PDB:5X6V [DatabaseIdentifier:12153899] PDB:6EHR [DatabaseIdentifier:12153914] PDB:7T3B [DatabaseIdentifier:12153917] PDB:5X6U [DatabaseIdentifier:12151848] PDB:9ED4 [DatabaseIdentifier:12153909] PDB:5Y39 [DatabaseIdentifier:11524814] ENSEMBL:ENSG00000109270 [DatabaseIdentifier:11646313] ENSEMBL:ENSP00000424183 [DatabaseIdentifier:11646312] ENSEMBL:ENSP00000226522 [DatabaseIdentifier:11769011] ENSEMBL:ENST00000226522 [DatabaseIdentifier:11769012] ENSEMBL:ENST00000499666 [DatabaseIdentifier:11795123] GeneCards:LAMTOR3 [DatabaseIdentifier:11848090] HPA:ENSG00000109270-LAMTOR3 [DatabaseIdentifier:12132776] OpenTargets:ENSG00000109270 [DatabaseIdentifier:12153907] PDB:7T3A [DatabaseIdentifier:12153912] PDB:7UXH [DatabaseIdentifier:12153918] PDB:6NZD [DatabaseIdentifier:12153900] PDB:6U62 [DatabaseIdentifier:12153903] PDB:9ED6 [DatabaseIdentifier:12153908] PDB:6B9X [DatabaseIdentifier:12153913] PDB:5YK3 [DatabaseIdentifier:12153902] PDB:6ULG
databaseName	UniProt
dbId	59307
description	recommendedName: fullName evidence="21"Ragulator complex protein LAMTOR3 alternativeName: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3 alternativeName: MEK-binding partner 1 shortName: Mp1 alternativeName: Mitogen-activated protein kinase kinase 1-interacting protein 1 alternativeName: Mitogen-activated protein kinase scaffold protein 1
displayName	UniProt:Q9UHA4 LAMTOR3
geneName	LAMTOR3 MAP2K1IP1 MAPKSP1 PRO2783
identifier	Q9UHA4
isSequenceChanged	false
keyword	3D-structure Alternative splicing Endosome Membrane Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	LAMTOR3
otherIdentifier	11718768_a_at 11718769_a_at 16978301 217971_PM_at 217971_at 227562_PM_at 227562_at 2779398 2779399 2779400 2779409 2779410 2779411 2779412 2779413 2779414 2779415 2779418 2779421 2779423 2779424 2779425 2779426 2779427 2872528 46103_at 46221_i_at 46222_r_at 8101925 8649 A_23_P110362 A_32_P10311 A_33_P3251480 GE80264 GE87054 GO:0005085 GO:0005515 GO:0005737 GO:0005765 GO:0005768 GO:0005770 GO:0005886 GO:0005925 GO:0008104 GO:0010008 GO:0016020 GO:0019209 GO:0031902 GO:0032006 GO:0032008 GO:0035579 GO:0038202 GO:0043410 GO:0060090 GO:0070062 GO:0070821 GO:0071230 GO:0071986 GO:0098772 GO:1902414 GO:1902533 GO:1904263 GO:1990877 HMNXSV003011044 Hs.332556.0.S1_3p_at ILMN_1659415 PH_hs_0030174 PH_hs_0037100 TC04001416.hg TC04002643.hg g11496276_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5653581] LAMTOR3 [lysosomal membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5693294] LAMTOR3 [endosome membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800178] LAMTOR3 [specific granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6806307] LAMTOR3 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800189] LAMTOR3 [tertiary granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000109270] ENSEMBL:ENSG00000109270 LAMTOR3 [ReferenceDNASequence:12770201] UCSC:Q9UHA4 LAMTOR3 [ReferenceDNASequence:11388608] BioGPS Gene:8649 LAMTOR3 [ReferenceDNASequence:11404190] COSMIC - genes:LAMTOR3 LAMTOR3 [ReferenceDNASequence:11424023] CTD Gene:8649 LAMTOR3 [ReferenceDNASequence:11441867] dbSNP Gene:8649 LAMTOR3 [ReferenceDNASequence:11826820] HGNC:15606 LAMTOR3 [ReferenceDNASequence:11924952] KEGG:hsa:8649 LAMTOR3 [ReferenceDNASequence:12018397] Monarch:8649 LAMTOR3 [ReferenceDNASequence:12102490] NCBI Gene:8649 LAMTOR3 [ReferenceDNASequence:12117092] OMIM:603296 LAMTOR3
referenceTranscript	[ReferenceRNASequence:12661669] RefSeq:NM_001243736.1 LAMTOR3 [ReferenceRNASequence:12661670] RefSeq:NM_021970.4 LAMTOR3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LTOR3_HUMAN B2R4A1 J3KMX4 Q9H364
sequenceLength	124
species	[Species:48887] Homo sapiens
stId	uniprot:Q9UHA4
url	http://purl.uniprot.org/uniprot/Q9UHA4

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