UniProt:Q9UH17 APOBEC3B

chain
  • chain:1-382
checksum DA6EDD23E8856240
comment
  • FUNCTION DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.CATALYTIC ACTIVITY a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+)COFACTOR Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1.INTERACTION Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues.INDUCTION Phorbol 12-myristate 13-acetate (PMA) induces overexpression in keratinocytes. Up-regulated by IFN-alpha.DOMAIN The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.MISCELLANEOUS It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.MISCELLANEOUS May be due to a competing donor splice site.SIMILARITY Belongs to the cytidine and deoxycytidylate deaminase family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Frameshifts result in two separate ORFs termed phorbolins 2 and 3.
crossReference
databaseName UniProt
dbId 61646
description
  • recommendedName: DNA dC->dU-editing enzyme APOBEC-3B shortName: A3B ecNumber: 3.5.4.38 alternativeName: Phorbolin-1-related protein alternativeName: Phorbolin-2/3
displayName UniProt:Q9UH17 APOBEC3B
geneName
  • APOBEC3B
identifier Q9UH17
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Antiviral defense
  • Hydrolase
  • Immunity
  • Innate immunity
  • Metal-binding
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repeat
  • RNA-binding
  • Zinc
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • APOBEC3B
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ABC3B_HUMAN
  • B0QYD2
  • O95618
  • Q20WL1
  • Q5IFJ4
  • Q7Z2N3
  • Q7Z6D6
  • Q9UE74
sequenceLength 382
species [Species:48887] Homo sapiens
stId uniprot:Q9UH17
url http://purl.uniprot.org/uniprot/Q9UH17
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