UniProt:Q9UBW5 BIN2

chain
  • chain:1-565
checksum B1D1FB89A97E9E43
comment
  • FUNCTION Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.SUBUNIT Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain), SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2.INTERACTION Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.ALTERNATIVE PRODUCTS Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.INDUCTION Up-regulated during monocytic differentiation.DOMAIN The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 220125
description
  • recommendedName: Bridging integrator 2 alternativeName: Breast cancer-associated protein 1
displayName UniProt:Q9UBW5 BIN2
geneName
  • BIN2
  • BRAP1
identifier Q9UBW5
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell junction
  • Cell membrane
  • Cell projection
  • Coiled coil
  • Cytoplasm
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • BIN2
otherIdentifier
  • 11720998_a_at
  • 11720999_a_at
  • 16764732
  • 219191_PM_s_at
  • 219191_s_at
  • 2733718
  • 3454842
  • 3454843
  • 3454844
  • 3454845
  • 3454846
  • 3454847
  • 3454848
  • 3454849
  • 3454850
  • 3454851
  • 3454852
  • 3454853
  • 3454854
  • 3454855
  • 3454856
  • 3454857
  • 3454858
  • 3454859
  • 3454860
  • 3454862
  • 3454863
  • 3454864
  • 3454865
  • 3454866
  • 51411
  • 58240_at
  • 76501_at
  • 7963289
  • A_23_P162386
  • GE53775
  • GO:0001891
  • GO:0002102
  • GO:0005515
  • GO:0005543
  • GO:0005576
  • GO:0005737
  • GO:0005886
  • GO:0005938
  • GO:0006911
  • GO:0016020
  • GO:0034774
  • GO:0042995
  • GO:0043226
  • GO:0048870
  • GO:0060326
  • GO:0061024
  • GO:0065003
  • GO:0070161
  • GO:0071800
  • GO:0097320
  • GO:1904813
  • HMNXSV003007778
  • ILMN_1726342
  • PH_hs_0031017
  • TC12001507.hg
  • g7706486_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BIN2_HUMAN
  • B7Z6F3
  • F5H0W4
  • Q86VV0
  • Q9NWK4
  • Q9UKN4
sequenceLength 565
species [Species:48887] Homo sapiens
stId uniprot:Q9UBW5
url http://purl.uniprot.org/uniprot/Q9UBW5
Cite Us!