UniProt:Q9UBS3 DNAJB9

chain
  • signal peptide:1-23
  • chain:24-223
checksum 59E3E57FF8B378BC
comment
  • FUNCTION Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).SUBUNIT Interacts with HSPA5/BiP; interaction is direct (By similarity). Interacts with ERN1/IRE1 (via the luminal region) (By similarity). Interacts with DERL1 (By similarity).INTERACTION Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248).DOMAIN The J domain stimulates the ATPase activity of HSPA5/BiP, while the divergent targeting domain is required for efficient substrate recognition by HSPA5/BiP. The divergent targeting domain specifically recognizes and binds to aggregation-prone sequences.
crossReference
databaseName UniProt
dbId 53690
description
  • recommendedName: fullName evidence="10"DnaJ homolog subfamily B member 9 alternativeName: fullName evidence="8"Endoplasmic reticulum DNA J domain-containing protein 4 shortName evidence="8"ER-resident protein ERdj4 shortName evidence="8"ERdj4 alternativeName: fullName evidence="9"Microvascular endothelial differentiation gene 1 protein shortName evidence="9"Mdg-1
displayName UniProt:Q9UBS3 DNAJB9
geneName
  • DNAJB9
  • MDG1
  • UNQ743/PRO1471
identifier Q9UBS3
isSequenceChanged false
keyword
  • 3D-structure
  • Chaperone
  • Endoplasmic reticulum
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Signal
  • Unfolded protein response
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • DNAJB9
otherIdentifier
  • 11730731_s_at
  • 11757735_s_at
  • 1554462_3p_a_at
  • 1554462_PM_a_at
  • 1554462_a_at
  • 17050328
  • 202842_PM_s_at
  • 202842_s_at
  • 202843_PM_at
  • 202843_at
  • 3018867
  • 3018868
  • 3018869
  • 3018870
  • 3018871
  • 3018872
  • 3018873
  • 3018874
  • 3018875
  • 3018876
  • 3018877
  • 3018878
  • 3018879
  • 3018880
  • 35799_at
  • 4189
  • 8135480
  • A_14_P136876
  • A_14_P201145
  • A_23_P258944
  • GE53682
  • GO:0002376
  • GO:0002639
  • GO:0005515
  • GO:0005730
  • GO:0005737
  • GO:0005783
  • GO:0005788
  • GO:0005789
  • GO:0006986
  • GO:0030154
  • GO:0030163
  • GO:0030183
  • GO:0030544
  • GO:0034976
  • GO:0036503
  • GO:0051087
  • GO:0051787
  • GO:0070062
  • GO:1903895
  • HMNXSV003048634
  • ILMN_1773742
  • PH_hs_0000684
  • TC07000699.hg
  • g5262493_3p_a_at
  • g9558754_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DNJB9_HUMAN
sequenceLength 223
species [Species:48887] Homo sapiens
stId uniprot:Q9UBS3
url http://purl.uniprot.org/uniprot/Q9UBS3

Referrals

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