UniProt:Q9UBM4 OPTC

chain
  • signal peptide:1-19
  • chain:20-332
checksum 8060B4C46DF41C20
comment
  • FUNCTION Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).SUBUNIT Homodimer.SUBCELLULAR LOCATION Expressed in cartilage and synovial membranes (at protein level) (PubMed:18164633, PubMed:23845380). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level) (PubMed:12019215, PubMed:25136834). Expressed in the retinal pigment epithelium (at protein level) (PubMed:25136834). Expressed in synovial fibroblasts and subchondral bone osteoblasts (PubMed:18164633).PTM O-glycosylated.PTM Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (PubMed:23845380). Proteolytically cleaved by MMP13 (By similarity). The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology (PubMed:23845380).PTM Sulfated on tyrosine residues.SIMILARITY Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
crossReference
databaseName UniProt
dbId 60966
description
  • recommendedName: Opticin alternativeName: Oculoglycan
displayName UniProt:Q9UBM4 OPTC
geneName
  • OPTC
  • OPT
identifier Q9UBM4
isSequenceChanged false
keyword
  • Disulfide bond
  • Extracellular matrix
  • Glycoprotein
  • Leucine-rich repeat
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Sulfation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • OPTC
otherIdentifier
  • 11726403_at
  • 16676172
  • 223884_PM_at
  • 223884_at
  • 26254
  • 4053112
  • 4053113
  • 4053114
  • 4053115
  • 4053116
  • 4053117
  • 4053118
  • 4053119
  • 4053120
  • 4053121
  • 4053122
  • 4053123
  • 4053124
  • 4053125
  • 4053126
  • 7908931
  • A_23_P97096
  • GO:0001525
  • GO:0005198
  • GO:0005201
  • GO:0005515
  • GO:0005576
  • GO:0016525
  • GO:0030198
  • GO:0030199
  • GO:0030312
  • GO:0031012
  • GO:0048856
  • GO:0060348
  • GO:0061975
  • HMNXSV003006727
  • ILMN_1781459
  • TC01001687.hg
  • g5639938_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • OPT_HUMAN
  • Q5T2G4
sequenceLength 332
species [Species:48887] Homo sapiens
stId uniprot:Q9UBM4
url http://purl.uniprot.org/uniprot/Q9UBM4
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