UniProt:Q9UBF8 PI4KB

chain
  • initiator methionine:1
  • chain:2-816
checksum CAD8791729BB4308
comment
  • FUNCTION Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development.FUNCTION (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).FUNCTION (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)COFACTOR Inhibited by wortmannin and adenosine (PubMed:11277933). Increased kinase activity upon interaction with NCS1/FREQ (By similarity).ACTIVITY REGULATION (Microbial infection) Activated by Aichi virus protein 3A, this activation is sensitized by ACBD3.BIOPHYSICOCHEMICAL PROPERTIES Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3 (PubMed:22124328, PubMed:22258260, PubMed:23572552, PubMed:27009356, PubMed:27989622). Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552). Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (PubMed:28289207). Interacts with ATG9A (PubMed:30917996).SUBUNIT (Microbial infection) Interacts with Aichi virus protein 3A. Part of a complex Aichi virus protein 3A/ACBD3/PI4KB that allows the synthesis of PI4P at the viral RNA replication sites.INTERACTION Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207). GGA2 is also involved in the recruitment (PubMed:28289207).ALTERNATIVE PRODUCTS Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver (PubMed:9020160, PubMed:9405935, PubMed:9405938). Expressed in the innear ear in the epithelium of the spinal organ of corti.DEVELOPMENTAL STAGE Expressed in 11-week old fetal inner ear.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 97632
description
  • recommendedName: fullName evidence="30"Phosphatidylinositol 4-kinase beta shortName: PI4K-beta shortName: PI4Kbeta shortName: PtdIns 4-kinase beta ecNumber evidence="8 22"2.7.1.67 alternativeName: NPIK alternativeName: PI4K92 alternativeName: fullName evidence="26 27"PI4KIII
displayName UniProt:Q9UBF8 PI4KB
geneName
  • PI4KB
  • PIK4CB
identifier Q9UBF8
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • ATP-binding
  • Cytoplasm
  • Deafness
  • Direct protein sequencing
  • Disease variant
  • Endoplasmic reticulum
  • Golgi apparatus
  • Host-virus interaction
  • Kinase
  • Lipid metabolism
  • Membrane
  • Mitochondrion
  • Mitochondrion outer membrane
  • Non-syndromic deafness
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transferase
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • PI4KB
otherIdentifier
  • 11737487_a_at
  • 11737488_s_at
  • 11744460_a_at
  • 11744461_s_at
  • 11747916_a_at
  • 11754312_s_at
  • 146_at
  • 16693030
  • 206138_PM_s_at
  • 206138_s_at
  • 206139_PM_at
  • 206139_at
  • 210417_PM_s_at
  • 210417_s_at
  • 2434926
  • 2434927
  • 2434928
  • 2434929
  • 2434931
  • 2434932
  • 2434933
  • 2434934
  • 2434935
  • 2434936
  • 2434937
  • 2434938
  • 2434939
  • 2434941
  • 2434942
  • 2434943
  • 2434944
  • 2434946
  • 2434947
  • 2434948
  • 2434949
  • 2434954
  • 2434959
  • 2434960
  • 2434961
  • 2434962
  • 2434964
  • 2434965
  • 2434966
  • 2434967
  • 2434968
  • 2434969
  • 2434970
  • 40253_at
  • 5298
  • 71609_at
  • 7919950
  • A_23_P103824
  • A_23_P314726
  • A_24_P222860
  • A_33_P3386726
  • GE55197
  • GE63232
  • GE831772
  • GO:0000139
  • GO:0000166
  • GO:0004430
  • GO:0005515
  • GO:0005524
  • GO:0005737
  • GO:0005739
  • GO:0005741
  • GO:0005768
  • GO:0005783
  • GO:0005794
  • GO:0005829
  • GO:0006629
  • GO:0006661
  • GO:0006898
  • GO:0007040
  • GO:0007165
  • GO:0012505
  • GO:0016020
  • GO:0016192
  • GO:0016301
  • GO:0016740
  • GO:0030867
  • GO:0046854
  • GO:0048015
  • GO:0048471
  • GO:0048839
  • GO:0048856
  • GO:0071889
  • HMNXSV003049481
  • HMNXSV003056989
  • ILMN_1666597
  • PH_hs_0009321
  • PH_hs_0039911
  • TC01003223.hg
  • U81802_at
  • g1894946_3p_a_at
  • g4505808_3p_a_at
  • g4505808_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PI4KB_HUMAN
  • B4DGI2
  • O15096
  • P78405
  • Q5VWB9
  • Q5VWC0
  • Q5VWC1
  • Q9BWR6
sequenceLength 816
species [Species:48887] Homo sapiens
stId uniprot:Q9UBF8
url http://purl.uniprot.org/uniprot/Q9UBF8
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