UniProt:Q9UBD6 RHCG

chain
  • chain:1-479
checksum E5D8024D720D4589
comment
  • FUNCTION Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:11062476, PubMed:14761968, PubMed:15929723, PubMed:16477434, PubMed:16580862, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989).CATALYTIC ACTIVITY NH4(+)(in) = NH4(+)(out)CATALYTIC ACTIVITY methylamine(out) = methylamine(in)CATALYTIC ACTIVITY CO2(out) = CO2(in)BIOPHYSICOCHEMICAL PROPERTIES Homotrimer.INTERACTION Also detected at the basolateral membrane and in subapical vesicles.TISSUE SPECIFICITY Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). Expressed in kidney.DEVELOPMENTAL STAGE Specifically expressed in fetal kidney.PTM N-glycosylated.SIMILARITY Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 245533
description
  • recommendedName: Ammonium transporter Rh type C alternativeName: Rh glycoprotein kidney alternativeName: Rhesus blood group family type C glycoprotein shortName: Rh family type C glycoprotein shortName: Rh type C glycoprotein alternativeName: Tumor-related protein DRC2
displayName UniProt:Q9UBD6 RHCG
geneName
  • RHCG
  • C15orf6
  • CDRC2
  • PDRC2
  • RHGK
identifier Q9UBD6
isSequenceChanged false
keyword
  • 3D-structure
  • Ammonia transport
  • Cell membrane
  • Glycoprotein
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • RHCG
otherIdentifier
  • 11724398_a_at
  • 11751020_a_at
  • 16813112
  • 219554_PM_at
  • 219554_at
  • 3638432
  • 3638433
  • 3638434
  • 3638435
  • 3638439
  • 3638440
  • 3638441
  • 3638442
  • 3638443
  • 3638444
  • 3638445
  • 3638446
  • 3638447
  • 3638449
  • 3638451
  • 3638452
  • 3638455
  • 3638461
  • 3638462
  • 51458
  • 7991283
  • A_23_P151975
  • GE62237
  • GO:0005515
  • GO:0005886
  • GO:0006873
  • GO:0006885
  • GO:0008092
  • GO:0008519
  • GO:0015837
  • GO:0016020
  • GO:0016323
  • GO:0016324
  • GO:0030154
  • GO:0030506
  • GO:0030855
  • GO:0031410
  • GO:0035378
  • GO:0035379
  • GO:0042592
  • GO:0042802
  • GO:0055085
  • GO:0070062
  • GO:0070634
  • GO:0072488
  • GO:0097272
  • HMNXSV003041436
  • ILMN_1778687
  • PH_hs_0014381
  • TC15001829.hg
  • g7706682_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RHCG_HUMAN
  • A8K4D4
  • Q6X3Y4
sequenceLength 479
species [Species:48887] Homo sapiens
stId uniprot:Q9UBD6
url http://purl.uniprot.org/uniprot/Q9UBD6
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