UniProt:Q9P296 C5AR2

chain
  • chain:1-337
checksum 53AF41B129FE8FE6
comment
  • FUNCTION Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:11773063). Also acts as a receptor for dearginated forms of C3a, C4a and C5a anaphylatoxin peptides (ASP/C3adesArg, C4adesArg and C5adesArg, respectively) (PubMed:12540846, PubMed:15833747, PubMed:19615750). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:12540846). C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:12540846).INTERACTION Frontal cortex, hippocampus, hypothalamus, pons and liver.SIMILARITY Belongs to the G-protein coupled receptor 1 family.
crossReference
databaseName UniProt
dbId 51114
description
  • recommendedName: C5a anaphylatoxin chemotactic receptor 2 alternativeName: fullName evidence="12"Complement component 5a receptor 2 alternativeName: G-protein coupled receptor 77
displayName UniProt:Q9P296 C5AR2
geneName
  • C5AR2
  • C5L2
  • GPR77
identifier Q9P296
isSequenceChanged false
keyword
  • Cell membrane
  • Disulfide bond
  • G-protein coupled receptor
  • Glycoprotein
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Transducer
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • C5AR2
otherIdentifier
  • 11737869_at
  • 16863593
  • 221149_PM_at
  • 221149_at
  • 27202
  • 3837127
  • 3837128
  • 3837270
  • 3837271
  • 3837272
  • 3837274
  • 3837275
  • 3837277
  • 3837278
  • 3837279
  • 3837280
  • 3837281
  • 3837282
  • 3837326
  • 79700_at
  • 8029914
  • 89539_at
  • A_23_P164943
  • A_33_P3223002
  • GE552756
  • GE555686
  • GE558290
  • GO:0002376
  • GO:0002430
  • GO:0002682
  • GO:0004875
  • GO:0004878
  • GO:0004930
  • GO:0005515
  • GO:0005886
  • GO:0006935
  • GO:0006954
  • GO:0007165
  • GO:0007186
  • GO:0007200
  • GO:0007204
  • GO:0009925
  • GO:0016020
  • GO:0032677
  • GO:0032715
  • GO:0032720
  • GO:0038178
  • GO:0045177
  • GO:0090024
  • HMNXSV003018957
  • ILMN_1669317
  • ILMN_1907649
  • PH_hs_0014597
  • TC19000677.hg
  • g8923872_3p_at
  • p8791
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • C5AR2_HUMAN
  • B2RA09
sequenceLength 337
species [Species:48887] Homo sapiens
stId uniprot:Q9P296
url http://purl.uniprot.org/uniprot/Q9P296

Referrals

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