UniProt:Q9P0L0 VAPA

chain
  • initiator methionine:1
  • chain:2-249
checksum 68B603F3A9FA5475
comment
  • FUNCTION Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).SUBUNIT Homodimer; disulfide-linked (PubMed:11511104, PubMed:33124732). Heterodimer with VAPB (PubMed:11511104). Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal domain of OCLN (PubMed:10523508, PubMed:11511104, PubMed:9657962). Interacts (via MSP domain) with OSBPL1A (via FFAT motif) (PubMed:33124732). Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation (PubMed:19289470, PubMed:21976701). Interacts with OSBP (PubMed:20178991). Interacts (via C-terminus) with RSAD2/viperin (via C-terminus) (PubMed:21957124). Interacts with IFITM3 (PubMed:23601107). Interacts with OSBPL3 (phosphorylated form) (PubMed:16143324, PubMed:25447204). Interacts with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts (via MSP domain) with STARD3 (via phosphorylated FFAT motif); this interaction recruits VAPA to the endosome (PubMed:24105263, PubMed:33124732). Interacts with STARD3NL (via FFAT motif) (PubMed:24105263). Interacts with CERT1 (PubMed:16895911). Interacts with PLEKHA3 and SACM1L to form a ternary complex (PubMed:30659099). Interacts with VPS13A (via FFAT motif) (PubMed:30741634). Interacts with RB1CC1 (via phosphorylated FFAT motif), MIGA2 (via phosphorylated FFAT motif), RMDN3 (via phosphorylated FFAT motif), KCNB1 (via phosphorylated FFAT motif) and KCNB2 (via phosphorylated FFAT motif) (PubMed:33124732). Interacts (via MSP domain) with WDR44 (via FFAT-like motif); the interactions connect the endoplasmic reticulum (ER) with the endosomal tubule (PubMed:32344433).SUBUNIT (Microbial infection) Interacts with HCV protein NS5A and NS5B (PubMed:21957124).INTERACTION Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells.ALTERNATIVE PRODUCTS Ubiquitous.DOMAIN The MSP domain binds the FFAT motif of many proteins.SIMILARITY Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 67104
description
  • recommendedName: fullName evidence="25"Vesicle-associated membrane protein-associated protein A shortName: VAMP-A shortName: VAMP-associated protein A shortName: VAP-A alternativeName: fullName evidence="24"33 kDa VAMP-associated protein shortName evidence="21 23"VAP-33
displayName UniProt:Q9P0L0 VAPA
geneName
  • VAPA
  • VAP33
identifier Q9P0L0
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cell junction
  • Cell membrane
  • Coiled coil
  • Disulfide bond
  • Endoplasmic reticulum
  • Host-virus interaction
  • Membrane
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Tight junction
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • VAPA
otherIdentifier
  • 11725316_x_at
  • 11725317_s_at
  • 11743255_a_at
  • 11743256_s_at
  • 11743257_x_at
  • 11754029_a_at
  • 11754086_x_at
  • 16850944
  • 208780_PM_x_at
  • 208780_x_at
  • 225198_PM_at
  • 225198_at
  • 228480_PM_at
  • 228480_at
  • 239750_PM_x_at
  • 239750_x_at
  • 242780_PM_at
  • 242780_at
  • 3638294
  • 3638295
  • 3778602
  • 3778603
  • 3778605
  • 3778609
  • 3778610
  • 3778612
  • 3778613
  • 3778614
  • 3778615
  • 3778618
  • 3778619
  • 3778620
  • 3778621
  • 3778622
  • 3778623
  • 3778626
  • 3778627
  • 3778628
  • 3778629
  • 3778630
  • 3778631
  • 3778632
  • 3778633
  • 38801_at
  • 46029_r_at
  • 54663_at
  • 63624_at
  • 8020129
  • 80694_at
  • 88498_at
  • 89329_at
  • 9218
  • A_23_P207957
  • A_23_P382199
  • A_33_P3419460
  • GE55653
  • GE576751
  • GE81305
  • GE86002
  • GE88533
  • GO:0000139
  • GO:0005515
  • GO:0005634
  • GO:0005783
  • GO:0005789
  • GO:0005829
  • GO:0005856
  • GO:0005886
  • GO:0005923
  • GO:0006629
  • GO:0006686
  • GO:0006888
  • GO:0008017
  • GO:0008092
  • GO:0015630
  • GO:0015914
  • GO:0015918
  • GO:0016020
  • GO:0016192
  • GO:0019076
  • GO:0019904
  • GO:0030301
  • GO:0031175
  • GO:0031965
  • GO:0031982
  • GO:0033149
  • GO:0035577
  • GO:0035627
  • GO:0042803
  • GO:0043123
  • GO:0043226
  • GO:0043495
  • GO:0044828
  • GO:0044829
  • GO:0045296
  • GO:0046982
  • GO:0048471
  • GO:0060090
  • GO:0061024
  • GO:0061025
  • GO:0061817
  • GO:0070161
  • GO:0070972
  • GO:0090114
  • HMNXSV003039333
  • Hs.150521.0.A1_3p_at
  • Hs.165195.0.S1_3p_at
  • Hs.165195.1.A1_3p_at
  • Hs.65082.0.A1_3p_at
  • ILMN_1690822
  • ILMN_1779410
  • ILMN_2405190
  • PH_hs_0029289
  • TC18000049.hg
  • g8099349_3p_a_at
  • g8099349_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • VAPA_HUMAN
  • A6NDZ0
  • D3DUI3
  • O75453
  • Q5U0E7
  • Q9UBZ2
sequenceLength 249
species [Species:48887] Homo sapiens
stId uniprot:Q9P0L0
url http://purl.uniprot.org/uniprot/Q9P0L0

Referrals

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