Reactome | UniProt:Q9NZ32 ACTR10

Schema > ReferenceGeneProduct > Entries

UniProt:Q9NZ32 ACTR10 Show undefined attributes

chain	chain:1-417
checksum	DF351A7B299DB7C1
comment	FUNCTION Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.SUBUNIT Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin.INTERACTION Belongs to the actin family.
crossReference	[DatabaseIdentifier:12316763] RefSeq:NP_060947.1 [DatabaseIdentifier:12283742] Pharos - Targets:Q9NZ32 [DatabaseIdentifier:12242591] PRO:Q9NZ32 [DatabaseIdentifier:12146948] PDB:9B7J [DatabaseIdentifier:12146949] PDB:9B85 [DatabaseIdentifier:12123423] OpenTargets:ENSG00000131966 [DatabaseIdentifier:11838909] HPA:ENSG00000131966-ACTR10 [DatabaseIdentifier:11801358] GlyGen:Q9NZ32 [DatabaseIdentifier:11785825] GeneCards:ACTR10 [DatabaseIdentifier:11659095] ENSEMBL:ENST00000254286 [DatabaseIdentifier:11536396] ENSEMBL:ENSP00000254286 [DatabaseIdentifier:11448128] ENSEMBL:ENSG00000131966
databaseName	UniProt
dbId	50311
description	recommendedName: Actin-related protein 10 alternativeName: Actin-related protein 11 shortName: hARP11
displayName	UniProt:Q9NZ32 ACTR10
geneName	ACTR10 ACTR11 ARP10 ARP11
identifier	Q9NZ32
isSequenceChanged	false
keyword	3D-structure Cytoplasm Cytoskeleton Proteomics identification Reference proteome
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	ACTR10
otherIdentifier	11715961_a_at 11715962_at 16784617 222230_PM_s_at 222230_s_at 3537815 3537816 3537821 3537822 3537823 3537824 3537826 3537827 3537828 3537829 3537830 3537831 3537832 3537833 3537834 3537835 3537836 3537837 3537838 3537839 3537840 3537841 3537842 55860 64288_s_at 65796_at 7974587 A_14_P110404 A_14_P118973 A_23_P151690 A_24_P253318 A_33_P3416946 GE62799 GO:0005515 GO:0005576 GO:0005737 GO:0005829 GO:0005856 GO:0005869 GO:0007018 GO:0035578 GO:0098958 GO:1904115 GO:1904813 HMNXSV003046656 Hs.274369.1.S1_3p_a_at ILMN_1798254 PH_hs_0023218 TC14000345.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6801556] ACTR10 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801072] ACTR10 [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6806245] ACTR10 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801080] ACTR10 [azurophil granule lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12671888] UCSC:Q9NZ32 ACTR10 [ReferenceDNASequence:12108945] OMIM:619731 ACTR10 [ReferenceDNASequence:12027594] NCBI Gene:55860 ACTR10 [ReferenceDNASequence:11943501] Monarch:55860 ACTR10 [ReferenceDNASequence:11857228] KEGG:hsa:55860 ACTR10 [ReferenceDNASequence:11817456] HGNC:17372 ACTR10 [ReferenceDNASequence:11427000] dbSNP Gene:55860 ACTR10 [ReferenceDNASequence:11410475] CTD Gene:55860 ACTR10 [ReferenceDNASequence:11391383] COSMIC - genes:ACTR10 ACTR10 [ReferenceDNASequence:11313712] BioGPS Gene:55860 ACTR10 [ReferenceDNASequence:ensembl:ENSG00000131966] ENSEMBL:ENSG00000131966 ACTR10
referenceTranscript	[ReferenceRNASequence:12498819] RefSeq:NM_018477.3 ACTR10
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ARP10_HUMAN Q9H9Y5 Q9NWY2
sequenceLength	417
species	[Species:48887] Homo sapiens
stId	uniprot:Q9NZ32
url	http://purl.uniprot.org/uniprot/Q9NZ32

Referrals

(interactor)	[UndirectedInteraction:11249069] UniProt:Q86WX3 <-> UniProt:Q9NZ32 (IntAct) [UndirectedInteraction:11241221] UniProt:P47756 <-> UniProt:Q9NZ32 (IntAct) [UndirectedInteraction:11201405] UniProt:Q14203 <-> UniProt:Q9NZ32 (IntAct) [UndirectedInteraction:11192763] UniProt:Q8N5V2 <-> UniProt:Q9NZ32 (IntAct) [UndirectedInteraction:11130423] UniProt:Q13227 <-> UniProt:Q9NZ32 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6801556] ACTR10 [cytosol] [EntityWithAccessionedSequence:R-HSA-6801072] ACTR10 [ficolin-1-rich granule lumen] [EntityWithAccessionedSequence:R-HSA-6806245] ACTR10 [extracellular region] [EntityWithAccessionedSequence:R-HSA-6801080] ACTR10 [azurophil granule lumen]