UniProt:Q9NYV7 TAS2R16

chain
  • chain:1-291
checksum 0693085F23D57D73
comment
  • FUNCTION Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.SUBUNIT Interacts with RTP3 and RTP4.SUBCELLULAR LOCATION Expressed in a subset of gustducin-positive taste receptor cells of the tongue. Expressed in circumvallate papillae and testis (PubMed:16720576).POLYMORPHISM Genetic variation in TAS2R16 influences sensitivity to beta-glucopyranoside tasting (BGLPT) [MIM:617956]. Variant Asn-172 results in greater receptor activation in response to bitter beta-glucopyranoside compounds including salicin, arbutin and amygdalin compared to Lys-172 (PubMed:16051168). Variant Lys-172 may influence risk of alcohol dependence (PubMed:16385453).MISCELLANEOUS Several bitter taste receptors are expressed in a single taste receptor cell.MISCELLANEOUS Confers bitter perception of salicin to non-taster mice.SIMILARITY Belongs to the G-protein coupled receptor T2R family.
crossReference
databaseName UniProt
dbId 102959
description
  • recommendedName: Taste receptor type 2 member 16 shortName: T2R16
displayName UniProt:Q9NYV7 TAS2R16
geneName
  • TAS2R16
identifier Q9NYV7
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • G-protein coupled receptor
  • Glycoprotein
  • Membrane
  • Receptor
  • Reference proteome
  • Sensory transduction
  • Taste
  • Transducer
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • TAS2R16
otherIdentifier
  • 11738764_at
  • 17062368
  • 221444_PM_at
  • 221444_at
  • 3070521
  • 3070522
  • 3070523
  • 3070524
  • 3070525
  • 50833
  • 8142624
  • A_23_P59825
  • GE80693
  • GO:0001580
  • GO:0004930
  • GO:0005515
  • GO:0005783
  • GO:0005802
  • GO:0005886
  • GO:0007165
  • GO:0007186
  • GO:0009897
  • GO:0016020
  • GO:0033038
  • GO:0050877
  • GO:0050909
  • HMNXSV003001509
  • ILMN_1706672
  • PH_hs_0014070
  • TC07001816.hg
  • g8394394_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • T2R16_HUMAN
  • A4D0X2
  • Q502V3
  • Q549U8
  • Q645W1
sequenceLength 291
species [Species:48887] Homo sapiens
stId uniprot:Q9NYV7
url http://purl.uniprot.org/uniprot/Q9NYV7
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