Reactome | UniProt:Q9NXR1 NDE1

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UniProt:Q9NXR1 NDE1 Show undefined attributes

chain	chain:1-335
checksum	FC0BDD8BB90324B8
comment	FUNCTION Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709).SUBUNIT Homodimer (PubMed:34793709). Interacts with CNTRL, LIS1, dynein, SLMAP and TCP1 (By similarity). Interacts with CENPF, dynactin, tubulin gamma, PAFAH1B1, PCM1 and PCNT. Interacts with ZNF365 (PubMed:16291865, PubMed:16682949, PubMed:17600710). Interacts with GTP-bound RAB9A and RAB9B; the interaction leads to RAB9-dynein motor tethering (PubMed:34793709). Interacts (via C-terminus) with MCRS1 (via C-terminus); phosphorylation of NDE1 inhibits the interaction (PubMed:16547491).INTERACTION Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis. Colocalizes with RAB9A to membrane vesicles (PubMed:34793709).ALTERNATIVE PRODUCTS Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum.PTM Phosphorylated in mitosis (PubMed:16682949). Phosphorylated in vitro by CDC2 (PubMed:16682949). Phosphorylation at Thr-246 is essential for the G2/M transition (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the nudE family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11442714] ENSEMBL:ENSG00000072864 [DatabaseIdentifier:11442715] ENSEMBL:ENSG00000275911 [DatabaseIdentifier:11528227] ENSEMBL:ENSP00000488199 [DatabaseIdentifier:11528226] ENSEMBL:ENSP00000502354 [DatabaseIdentifier:11528229] ENSEMBL:ENSP00000502635 [DatabaseIdentifier:11528225] ENSEMBL:ENSP00000379642 [DatabaseIdentifier:11528230] ENSEMBL:ENSP00000502160 [DatabaseIdentifier:11528224] ENSEMBL:ENSP00000501936 [DatabaseIdentifier:11528223] ENSEMBL:ENSP00000488050 [DatabaseIdentifier:11528228] ENSEMBL:ENSP00000379643 [DatabaseIdentifier:11650927] ENSEMBL:ENST00000674888 [DatabaseIdentifier:11650928] ENSEMBL:ENST00000631844 [DatabaseIdentifier:11650923] ENSEMBL:ENST00000675951 [DatabaseIdentifier:11650925] ENSEMBL:ENST00000674554 [DatabaseIdentifier:11650924] ENSEMBL:ENST00000396354 [DatabaseIdentifier:11650922] ENSEMBL:ENST00000396355 [DatabaseIdentifier:11650926] ENSEMBL:ENST00000631923 [DatabaseIdentifier:11650929] ENSEMBL:ENST00000675926 [DatabaseIdentifier:11781867] GeneCards:NDE1 [DatabaseIdentifier:11797566] GlyGen:Q9NXR1 [DatabaseIdentifier:11834991] HPA:ENSG00000072864-NDE1 [DatabaseIdentifier:12119442] OpenTargets:ENSG00000072864 [DatabaseIdentifier:12135043] Orphanet:NDE1 [DatabaseIdentifier:12141356] PDB:7E1T [DatabaseIdentifier:12236372] PRO:Q9NXR1 [DatabaseIdentifier:12279780] Pharos - Targets:Q9NXR1 [DatabaseIdentifier:12305242] RefSeq:XP_054236512.1 [DatabaseIdentifier:12305241] RefSeq:XP_054185079.1 [DatabaseIdentifier:12305244] RefSeq:NP_001137451.1 [DatabaseIdentifier:12305245] RefSeq:NP_060138.1 [DatabaseIdentifier:12305243] RefSeq:XP_016878838.1
databaseName	UniProt
dbId	239024
description	recommendedName: Nuclear distribution protein nudE homolog 1 shortName: NudE
displayName	UniProt:Q9NXR1 NDE1
geneName	NDE1 NUDE
identifier	Q9NXR1
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome Coiled coil Cytoplasm Cytoplasmic vesicle Cytoskeleton Developmental protein Differentiation Kinetochore Lipoprotein Lissencephaly Membrane Microtubule Mitosis Neurogenesis Palmitate Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	NDE1
otherIdentifier	11725110_a_at 11725111_at 11725112_at 11756077_a_at 16816200 218414_PM_s_at 218414_s_at 222625_PM_s_at 222625_s_at 227843_at 230219_PM_at 230219_at 239307_PM_at 239307_at 3649812 3649813 3649814 3649815 3649817 3649818 3649821 3649822 3649823 3649824 3649827 3649830 3649831 3649832 3649833 3649836 3649839 3649840 3649841 3649846 3649848 3649849 3649850 3649856 3649857 3649858 3649860 43376_at 45364_at 45365_g_at 54820 7993467 84271_r_at A_23_P206901 A_24_P210675 A_32_P15898 GE82201 GE84761 GO:0000132 GO:0000775 GO:0000776 GO:0001764 GO:0005515 GO:0005694 GO:0005737 GO:0005813 GO:0005815 GO:0005819 GO:0005829 GO:0005856 GO:0005871 GO:0005874 GO:0007010 GO:0007018 GO:0007020 GO:0007059 GO:0007100 GO:0007399 GO:0007405 GO:0008017 GO:0008092 GO:0016020 GO:0016477 GO:0019904 GO:0021987 GO:0030154 GO:0030659 GO:0030900 GO:0031023 GO:0031410 GO:0031616 GO:0032154 GO:0042802 GO:0043226 GO:0045202 GO:0047496 GO:0048856 GO:0048870 GO:0051298 GO:0051301 GO:0051303 GO:0051642 HMNXSV003005363 HMNXSV003015595 HMNXSV003015915 HMNXSV003026620 HMNXSV003057023 Hs.263925.0.S1_3p_a_at Hs.263925.0.S1_3p_x_at Hs.263925.1.A1_3p_at Hs.308305.0.A1_3p_at ILMN_1739805 PH_hs_0013649 TC16000192.hg g8923109_3p_a_at p6298
physicalEntity	[EntityWithAccessionedSequence:R-HSA-376257] NDE1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000072864] ENSEMBL:ENSG00000072864 NDE1 [ReferenceDNASequence:12668778] UCSC:Q9NXR1 NDE1 [ReferenceDNASequence:11308256] BioGPS Gene:54820 NDE1 [ReferenceDNASequence:11391020] COSMIC - genes:NDE1 NDE1 [ReferenceDNASequence:11405043] CTD Gene:54820 NDE1 [ReferenceDNASequence:11426558] dbSNP Gene:54820 NDE1 [ReferenceDNASequence:11813468] HGNC:17619 NDE1 [ReferenceDNASequence:11852066] KEGG:hsa:54820 NDE1 [ReferenceDNASequence:11938045] Monarch:54820 NDE1 [ReferenceDNASequence:12022138] NCBI Gene:54820 NDE1 [ReferenceDNASequence:12105342] OMIM:609449 NDE1
referenceTranscript	[ReferenceRNASequence:12487375] RefSeq:NM_001143979.2 NDE1 [ReferenceRNASequence:12487376] RefSeq:XM_017023349.3 NDE1 [ReferenceRNASequence:12487377] RefSeq:XM_054329104.1 NDE1 [ReferenceRNASequence:12487373] RefSeq:XM_054380537.1 NDE1 [ReferenceRNASequence:12487374] RefSeq:NM_017668.3 NDE1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NDE1_HUMAN Q49AQ2
sequenceLength	335
species	[Species:48887] Homo sapiens
stId	uniprot:Q9NXR1
url	http://purl.uniprot.org/uniprot/Q9NXR1

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-376257] NDE1 [cytosol]
(interactor)	[UndirectedInteraction:11151713] UniProt:P63005 <-> UniProt:Q9NXR1 (IntAct) [UndirectedInteraction:11177535] UniProt:P43034 <-> UniProt:Q9NXR1 (IntAct) [UndirectedInteraction:11264809] UniProt:P62258 <-> UniProt:Q9NXR1 (IntAct)