Reactome | UniProt:Q9NVM4 PRMT7

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UniProt:Q9NVM4 PRMT7 Show undefined attributes

chain	chain:1-692
checksum	9E0DB9530154231C
comment	FUNCTION Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.CATALYTIC ACTIVITY L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)SUBUNIT Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.INTERACTION The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.SEQUENCE CAUTION Truncated N-terminus.
crossReference	[DatabaseIdentifier:11444589] ENSEMBL:ENSG00000132600 [DatabaseIdentifier:11531056] ENSEMBL:ENSP00000409324 [DatabaseIdentifier:11531058] ENSEMBL:ENSP00000509003 [DatabaseIdentifier:11531059] ENSEMBL:ENSP00000343103 [DatabaseIdentifier:11531060] ENSEMBL:ENSP00000510748 [DatabaseIdentifier:11531057] ENSEMBL:ENSP00000414716 [DatabaseIdentifier:11653759] ENSEMBL:ENST00000449359 [DatabaseIdentifier:11653755] ENSEMBL:ENST00000441236 [DatabaseIdentifier:11653756] ENSEMBL:ENST00000692760 [DatabaseIdentifier:11653758] ENSEMBL:ENST00000687558 [DatabaseIdentifier:11653757] ENSEMBL:ENST00000339507 [DatabaseIdentifier:11780330] Guide to Pharmacology - Targets:1258 [DatabaseIdentifier:11783252] GeneCards:PRMT7 [DatabaseIdentifier:11798868] GlyGen:Q9NVM4 [DatabaseIdentifier:11830768] HMDB Protein:HMDBP11617 [DatabaseIdentifier:11836362] HPA:ENSG00000132600-PRMT7 [DatabaseIdentifier:12120836] OpenTargets:ENSG00000132600 [DatabaseIdentifier:12135888] Orphanet:PRMT7 [DatabaseIdentifier:12238545] PRO:Q9NVM4 [DatabaseIdentifier:12281169] Pharos - Targets:Q9NVM4 [DatabaseIdentifier:12309398] RefSeq:NP_061896.1 [DatabaseIdentifier:12309399] RefSeq:NP_001171753.1 [DatabaseIdentifier:12309397] RefSeq:NP_001364947.1 [DatabaseIdentifier:12309396] RefSeq:XP_054236478.1 [DatabaseIdentifier:12309394] RefSeq:XP_054236459.1 [DatabaseIdentifier:12309400] RefSeq:XP_054236480.1 [DatabaseIdentifier:12309393] RefSeq:XP_054236479.1 [DatabaseIdentifier:12309395] RefSeq:NP_001276947.1
databaseName	UniProt
dbId	50014
description	recommendedName: Protein arginine N-methyltransferase 7 ecNumber evidence="8"2.1.1.321 alternativeName: Histone-arginine N-methyltransferase PRMT7 alternativeName: [Myelin basic protein]-arginine N-methyltransferase PRMT7
displayName	UniProt:Q9NVM4 PRMT7
geneName	PRMT7 KIAA1933
identifier	Q9NVM4
isSequenceChanged	false
keyword	Alternative splicing Chromatin regulator Cytoplasm Differentiation Disease variant Dwarfism Intellectual disability Methylation Methyltransferase Nucleus Proteomics identification Reference proteome Repeat S-adenosyl-L-methionine Transcription Transcription regulation Transferase
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	PRMT7
otherIdentifier	11736151_a_at 11745439_x_at 16820414 219408_PM_at 219408_at 3666190 3666191 3666192 3666194 3666195 3666196 3666197 3666198 3666199 3666200 3666201 3666202 3666203 3666204 3666205 3666206 3666207 3666208 3666209 3666210 3666211 3666212 3666213 3666214 3666215 3666216 3666217 3666219 3666220 3666221 3666222 3666223 3666224 3666225 3666226 3666227 3666228 3666229 3666230 3666231 3666232 3666233 3666234 3666235 3666237 3666238 3666241 3666242 3666244 48349_at 50633_at 54496 79181_at 7996785 84653_at A_14_P139664 A_23_P77430 A_23_P77437 A_33_P3246863 GE80821 GO:0000387 GO:0001650 GO:0003824 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006325 GO:0006338 GO:0006355 GO:0006479 GO:0008168 GO:0008276 GO:0008757 GO:0016274 GO:0016740 GO:0018216 GO:0030154 GO:0032259 GO:0035241 GO:0035243 GO:0042054 GO:0042393 GO:0043021 GO:0044020 GO:0071514 GO:0140096 GO:0140939 HMNXSV003038020 HMNXSV003039191 HMNXSV003045484 ILMN_2082489 PH_hs_0005097 TC16000555.hg g9506614_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5225643] PRMT7 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12669860] UCSC:Q9NVM4 PRMT7 [ReferenceDNASequence:ensembl:ENSG00000132600] ENSEMBL:ENSG00000132600 PRMT7 [ReferenceDNASequence:11310243] BioGPS Gene:54496 PRMT7 [ReferenceDNASequence:11391151] COSMIC - genes:PRMT7 PRMT7 [ReferenceDNASequence:11406874] CTD Gene:54496 PRMT7 [ReferenceDNASequence:11426731] dbSNP Gene:54496 PRMT7 [ReferenceDNASequence:11814868] HGNC:25557 PRMT7 [ReferenceDNASequence:11853953] KEGG:hsa:54496 PRMT7 [ReferenceDNASequence:11940032] Monarch:54496 PRMT7 [ReferenceDNASequence:12024125] NCBI Gene:54496 PRMT7 [ReferenceDNASequence:12106596] OMIM:610087 PRMT7
referenceTranscript	[ReferenceRNASequence:12491496] RefSeq:XM_054380484.1 PRMT7 [ReferenceRNASequence:12491491] RefSeq:NM_019023.5 PRMT7 [ReferenceRNASequence:12491492] RefSeq:XM_054380504.1 PRMT7 [ReferenceRNASequence:12491493] RefSeq:XM_054380505.1 PRMT7 [ReferenceRNASequence:12491494] RefSeq:XM_054380503.1 PRMT7 [ReferenceRNASequence:12491490] RefSeq:NM_001184824.4 PRMT7 [ReferenceRNASequence:12491489] RefSeq:NM_001378018.1 PRMT7 [ReferenceRNASequence:12491495] RefSeq:NM_001290018.2 PRMT7
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ANM7_HUMAN B3KPR0 B3KUG9 B4E379 Q96PV5 Q9H9L0
sequenceLength	692
species	[Species:48887] Homo sapiens
stId	uniprot:Q9NVM4
url	http://purl.uniprot.org/uniprot/Q9NVM4

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-5225643] PRMT7 [nucleoplasm]