Reactome | UniProt:Q9NVC6 MED17

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UniProt:Q9NVC6 MED17 Show undefined attributes

chain	chain:1-651
checksum	47011210952D287B
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Interacts with GATA1 and PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2.INTERACTION Ubiquitous.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be due to intron retention.SIMILARITY Belongs to the Mediator complex subunit 17 family.
crossReference	[DatabaseIdentifier:11531327] ENSEMBL:ENSP00000251871 [DatabaseIdentifier:12309822] RefSeq:NP_004259.3 [DatabaseIdentifier:12281362] Pharos - Targets:Q9NVC6 [DatabaseIdentifier:12238798] PRO:Q9NVC6 [DatabaseIdentifier:12138290] PDB:7LBM [DatabaseIdentifier:12139975] PDB:7ENJ [DatabaseIdentifier:12139979] PDB:8TRH [DatabaseIdentifier:12139980] PDB:7ENC [DatabaseIdentifier:12139983] PDB:7EMF [DatabaseIdentifier:12139978] PDB:8TQW [DatabaseIdentifier:12139981] PDB:7NVR [DatabaseIdentifier:12139982] PDB:7ENA [DatabaseIdentifier:12139984] PDB:8T9D [DatabaseIdentifier:12139977] PDB:8GXQ [DatabaseIdentifier:12139976] PDB:8GXS [DatabaseIdentifier:12136001] Orphanet:MED17 [DatabaseIdentifier:12121029] OpenTargets:ENSG00000042429 [DatabaseIdentifier:11836553] HPA:ENSG00000042429-MED17 [DatabaseIdentifier:11799026] GlyGen:Q9NVC6 [DatabaseIdentifier:11783443] GeneCards:MED17 [DatabaseIdentifier:11654026] ENSEMBL:ENST00000251871 [DatabaseIdentifier:11444785] ENSEMBL:ENSG00000042429
databaseName	UniProt
dbId	52868
description	recommendedName: Mediator of RNA polymerase II transcription subunit 17 alternativeName: Activator-recruited cofactor 77 kDa component shortName: ARC77 alternativeName: Cofactor required for Sp1 transcriptional activation subunit 6 shortName: CRSP complex subunit 6 alternativeName: Mediator complex subunit 17 alternativeName: Thyroid hormone receptor-associated protein complex 80 kDa component shortName: Trap80 alternativeName: Transcriptional coactivator CRSP77 alternativeName: Vitamin D3 receptor-interacting protein complex 80 kDa component shortName: DRIP80
displayName	UniProt:Q9NVC6 MED17
geneName	MED17 ARC77 CRSP6 DRIP77 DRIP80 TRAP80
identifier	Q9NVC6
isSequenceChanged	false
keyword	3D-structure Activator Alternative splicing Direct protein sequencing Disease variant Nucleus Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	MED17
otherIdentifier	11718042_at 11718043_a_at 16730124 16730153 221517_PM_s_at 221517_s_at 223115_PM_at 223115_at 232483_PM_at 232483_at 3344898 3344899 3344902 3344903 3344904 3344905 3344906 3344907 3344908 3344909 3344910 3344911 3344912 3344913 3344914 3344915 3344916 3344917 3344918 3344919 3344921 3344922 3344923 3344924 3344925 3344926 3344927 3344928 3344929 3344931 56319_at 61124_at 72039_at 7943176 7943191 7943193 88836_at 9440 A_14_P108974 A_14_P119561 A_23_P116025 A_24_P218587 A_24_P941459 GE55869 GE639667 GE88704 GO:0000151 GO:0003712 GO:0003713 GO:0003824 GO:0005515 GO:0005634 GO:0005654 GO:0005667 GO:0006355 GO:0006357 GO:0006367 GO:0016020 GO:0016567 GO:0016592 GO:0016740 GO:0032968 GO:0035019 GO:0042809 GO:0045893 GO:0045944 GO:0046966 GO:0051123 GO:0060261 GO:0061630 GO:0065003 GO:0070847 GO:0140096 HMNXSV003022957 Hs.22630.1.S2_3p_at Hs.29438.0.S1_3p_at ILMN_1730329 PH_hs_0031069 RNA144170\|snRNA_123_199 TC11000912.hg TC11000913.hg g4838128_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-212401] MED17 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000042429] ENSEMBL:ENSG00000042429 MED17 [ReferenceDNASequence:12669948] UCSC:Q9NVC6 MED17 [ReferenceDNASequence:12106777] OMIM:603810 MED17 [ReferenceDNASequence:12024340] NCBI Gene:9440 MED17 [ReferenceDNASequence:11940247] Monarch:9440 MED17 [ReferenceDNASequence:11854163] KEGG:hsa:9440 MED17 [ReferenceDNASequence:11815060] HGNC:2375 MED17 [ReferenceDNASequence:11310458] BioGPS Gene:9440 MED17 [ReferenceDNASequence:11391164] COSMIC - genes:MED17 MED17 [ReferenceDNASequence:11407101] CTD Gene:9440 MED17 [ReferenceDNASequence:11426747] dbSNP Gene:9440 MED17
referenceTranscript	[ReferenceRNASequence:12491905] RefSeq:NM_004268.4 MED17
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MED17_HUMAN B3KN07 Q9HA81 Q9UNP7 Q9Y2W0 Q9Y660
sequenceLength	651
species	[Species:48887] Homo sapiens
stId	uniprot:Q9NVC6
url	http://purl.uniprot.org/uniprot/Q9NVC6

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[EntityWithAccessionedSequence:R-HSA-212401] MED17 [nucleoplasm]

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