Reactome | UniProt:Q9NSD7 RXFP3

Schema > ReferenceGeneProduct > Entries

UniProt:Q9NSD7 RXFP3 Show undefined attributes

chain	chain:1-469
checksum	932E7B3001689F7B
comment	FUNCTION Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.SUBCELLULAR LOCATION Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.SIMILARITY Belongs to the G-protein coupled receptor 1 family.
crossReference	[DatabaseIdentifier:12816688] ZINC target:Q9NSD7 [DatabaseIdentifier:12813285] ZINC - Substances:RL3R1_HUMAN [DatabaseIdentifier:12392153] RefSeq:NP_057652.1 [DatabaseIdentifier:12293592] Pharos - Targets:Q9NSD7 [DatabaseIdentifier:12276797] PRO:Q9NSD7 [DatabaseIdentifier:12229892] PDB:9KFJ [DatabaseIdentifier:12139264] PDB:9KFI [DatabaseIdentifier:12133424] OpenTargets:ENSG00000182631 [DatabaseIdentifier:11848733] HPA:ENSG00000182631-RXFP3 [DatabaseIdentifier:11832869] HMDB Protein:HMDBP08167 [DatabaseIdentifier:11811551] GlyGen:Q9NSD7 [DatabaseIdentifier:11795765] GeneCards:RXFP3 [DatabaseIdentifier:11779639] Guide to Pharmacology - Targets:353 [DatabaseIdentifier:11708133] ENSEMBL:ENST00000616205 [DatabaseIdentifier:11708132] ENSEMBL:ENST00000330120 [DatabaseIdentifier:11585433] ENSEMBL:ENSP00000328708 [DatabaseIdentifier:11585434] ENSEMBL:ENSP00000480733 [DatabaseIdentifier:11483386] ENSEMBL:ENSG00000182631 [DatabaseIdentifier:11483387] ENSEMBL:ENSG00000277069
databaseName	UniProt
dbId	64132
description	recommendedName: Relaxin-3 receptor 1 shortName: RLN3 receptor 1 alternativeName: G protein-coupled receptor SALPR alternativeName: G-protein coupled receptor GPCR135 alternativeName: Relaxin family peptide receptor 3 alternativeName: Somatostatin- and angiotensin-like peptide receptor
displayName	UniProt:Q9NSD7 RXFP3
geneName	RXFP3 GPCR135 RLN3R1 SALPR
identifier	Q9NSD7
isSequenceChanged	false
keyword	3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	RXFP3
otherIdentifier	11732048_at 16983836 221066_PM_at 221066_at 2805940 2805941 2805942 2805943 2805944 2805945 2805946 2805947 2805948 2805949 2805950 2805951 51289 8104781 A_23_P363365 GE80609 GO:0004930 GO:0004966 GO:0005886 GO:0007165 GO:0007186 GO:0007218 GO:0016020 GO:0032467 HMNXSV003038226 ILMN_1731621 PH_hs_0010157 TC05000149.hg g7706102_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-444841] RXFP3 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12694760] UCSC:Q9NSD7 RXFP3 [ReferenceDNASequence:12117692] OMIM:609445 RXFP3 [ReferenceDNASequence:12062664] NCBI Gene:51289 RXFP3 [ReferenceDNASequence:11978571] Monarch:51289 RXFP3 [ReferenceDNASequence:11888721] KEGG:hsa:51289 RXFP3 [ReferenceDNASequence:11827470] HGNC:24883 RXFP3 [ReferenceDNASequence:11429365] dbSNP Gene:51289 RXFP3 [ReferenceDNASequence:11424803] CTD Gene:51289 RXFP3 [ReferenceDNASequence:11393408] COSMIC - genes:RXFP3 RXFP3 [ReferenceDNASequence:11348782] BioGPS Gene:51289 RXFP3 [ReferenceDNASequence:ensembl:ENSG00000182631] ENSEMBL:ENSG00000182631 RXFP3
referenceTranscript	[ReferenceRNASequence:12573901] RefSeq:NM_016568.3 RXFP3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RL3R1_HUMAN Q14DA5
sequenceLength	469
species	[Species:48887] Homo sapiens
stId	uniprot:Q9NSD7
url	http://purl.uniprot.org/uniprot/Q9NSD7

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-444841] RXFP3 [plasma membrane]