UniProt:Q9NS56 TOPORS

chain
  • chain:1-1045
checksum 3DA635FDB5C83B77
comment
  • FUNCTION Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SUBUNIT Interacts with PARK7/DJ-1 (By similarity). Interacts with TOP1. Interacts with p53/TP53; can both ubiquitinate and sumoylate p53/TP53. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage.INTERACTION Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.ALTERNATIVE PRODUCTS Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers.INDUCTION By genotoxic agents such as cisplatin and camptothecin.PTM Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation.PTM Sumoylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.CAUTION Was originally thought to bind to the palindromic consensus sequence 5'-TCCCAGCACTTTGGGA-3' and to regulate the transcription of numerous genes in the lung.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 252272
description
  • recommendedName: E3 ubiquitin-protein ligase Topors ecNumber: 2.3.2.27 alternativeName: fullName evidence="20"RING-type E3 ubiquitin transferase Topors alternativeName: SUMO1-protein E3 ligase Topors alternativeName: Topoisomerase I-binding RING finger protein alternativeName: Topoisomerase I-binding arginine/serine-rich protein alternativeName: Tumor suppressor p53-binding protein 3 shortName: p53-binding protein 3 shortName: p53BP3
displayName UniProt:Q9NS56 TOPORS
geneName
  • TOPORS
  • LUN
  • TP53BPL
identifier Q9NS56
isSequenceChanged false
keyword
  • Alternative splicing
  • DNA damage
  • Isopeptide bond
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Retinitis pigmentosa
  • Transferase
  • Ubl conjugation
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • TOPORS
otherIdentifier
  • 10210
  • 11732260_a_at
  • 17093117
  • 204071_PM_s_at
  • 204071_s_at
  • 3203136
  • 3203137
  • 3203138
  • 3203139
  • 3203140
  • 3203141
  • 3203142
  • 3203143
  • 3203144
  • 3203145
  • 3203146
  • 3203147
  • 3203148
  • 3203149
  • 3203150
  • 3203154
  • 3203157
  • 3203158
  • 3203159
  • 38568_at
  • 8160581
  • A_23_P32217
  • GE58383
  • GO:0000151
  • GO:0000209
  • GO:0000922
  • GO:0000930
  • GO:0003677
  • GO:0003823
  • GO:0003824
  • GO:0004842
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005814
  • GO:0005815
  • GO:0006351
  • GO:0006355
  • GO:0006511
  • GO:0006513
  • GO:0006974
  • GO:0008270
  • GO:0008630
  • GO:0010842
  • GO:0016605
  • GO:0016607
  • GO:0016740
  • GO:0016925
  • GO:0019789
  • GO:0030163
  • GO:0030496
  • GO:0032391
  • GO:0034504
  • GO:0035845
  • GO:0036064
  • GO:0042127
  • GO:0042771
  • GO:0043066
  • GO:0043161
  • GO:0043226
  • GO:0044547
  • GO:0045893
  • GO:0046872
  • GO:0051457
  • GO:0061630
  • GO:0070936
  • GO:0140096
  • HMNXSV003024074
  • ILMN_1749218
  • ILMN_2122669
  • PH_hs_0026080
  • TC09001000.hg
  • g5032190_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TOPRS_HUMAN
  • O43273
  • Q6P987
  • Q9NS55
  • Q9UNR9
sequenceLength 1045
species [Species:48887] Homo sapiens
stId uniprot:Q9NS56
url http://purl.uniprot.org/uniprot/Q9NS56
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