UniProt:Q9NRA2 SLC17A5

chain
  • chain:1-495
checksum 5C6C154B3E93A19E
comment
  • FUNCTION Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity) (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (PubMed:22778404). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (By similarity) (PubMed:21781115, PubMed:22778404, PubMed:23889254).FUNCTION Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.CATALYTIC ACTIVITY N-acetylneuraminate(in) + H(+)(in) = N-acetylneuraminate(out) + H(+)(out)CATALYTIC ACTIVITY D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)CATALYTIC ACTIVITY 2 nitrate(out) + H(+)(out) = 2 nitrate(in) + H(+)(in)CATALYTIC ACTIVITY L-aspartate(out) = L-aspartate(in)CATALYTIC ACTIVITY L-glutamate(out) = L-glutamate(in)CATALYTIC ACTIVITY N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)BIOPHYSICOCHEMICAL PROPERTIES In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues (PubMed:10581036, PubMed:11751519). Highly expressed in salivary glands and liver, with lower levels of expression in brain, spleen kidney, muscle and pancreas. Expressed in acinar cells of salivary glands (at protein level) (PubMed:22778404).DEVELOPMENTAL STAGE Found in fetal lung and small intestine, and at lower level in fetal skin and muscle.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 153454
description
  • recommendedName: Sialin alternativeName: H(+)/nitrate cotransporter alternativeName: H(+)/sialic acid cotransporter shortName: AST alternativeName: fullName evidence="16"Membrane glycoprotein HP59 alternativeName: Solute carrier family 17 member 5 alternativeName: fullName evidence="2"Vesicular excitatory amino acid transporter shortName evidence="2"VEAT
displayName UniProt:Q9NRA2 SLC17A5
geneName
  • SLC17A5
identifier Q9NRA2
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Amino-acid transport
  • Cell membrane
  • Cytoplasmic vesicle
  • Disease variant
  • Glycoprotein
  • Lysosome
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Symport
  • Synapse
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • SLC17A5
otherIdentifier
  • 11723476_at
  • 11723477_x_at
  • 11752119_x_at
  • 11753191_a_at
  • 11758156_s_at
  • 17020823
  • 221041_PM_s_at
  • 221041_s_at
  • 223441_PM_at
  • 223441_at
  • 26503
  • 2960959
  • 2960960
  • 2960961
  • 2960962
  • 2960963
  • 2960964
  • 2960968
  • 2960970
  • 2960971
  • 2960972
  • 2960976
  • 2960977
  • 2960978
  • 2960979
  • 2960980
  • 2960982
  • 2960983
  • 2960994
  • 2960995
  • 2960996
  • 2960997
  • 65644_at
  • 8127549
  • 88617_at
  • A_23_P110896
  • A_33_P3265270
  • A_33_P3416321
  • GE58496
  • GO:0005351
  • GO:0005764
  • GO:0005765
  • GO:0005829
  • GO:0005886
  • GO:0006811
  • GO:0006820
  • GO:0006865
  • GO:0009617
  • GO:0015136
  • GO:0015293
  • GO:0015538
  • GO:0015739
  • GO:0016020
  • GO:0016323
  • GO:0016324
  • GO:0022857
  • GO:0030672
  • GO:0031410
  • GO:0034219
  • GO:0042874
  • GO:0042880
  • GO:0045202
  • GO:0046942
  • GO:0055085
  • GO:0098700
  • GO:0098978
  • GO:1902600
  • HMNXSV003032940
  • Hs.117865.1.S2_3p_at
  • ILMN_1684434
  • PH_hs_0006462
  • TC06001876.hg
  • g6912665_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • S17A5_HUMAN
  • Q5SZ76
  • Q8NBR5
  • Q9UGH0
sequenceLength 495
species [Species:48887] Homo sapiens
stId uniprot:Q9NRA2
url http://purl.uniprot.org/uniprot/Q9NRA2
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