Reactome | UniProt:Q9NR81 ARHGEF3

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UniProt:Q9NR81 ARHGEF3 Show undefined attributes

chain	chain:1-526
checksum	0FE8248AB52D1CBC
comment	FUNCTION Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.SUBUNIT Interacts with RHOA and RHOB.INTERACTION Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:12392622] RefSeq:NP_001276627.1 [DatabaseIdentifier:12392623] RefSeq:XP_047304180.1 [DatabaseIdentifier:12392624] RefSeq:NP_001364336.1 [DatabaseIdentifier:12392625] RefSeq:NP_062455.1 [DatabaseIdentifier:12392621] RefSeq:NP_001122087.1 [DatabaseIdentifier:12392619] RefSeq:XP_047304178.1 [DatabaseIdentifier:12392618] RefSeq:XP_047304179.1 [DatabaseIdentifier:12392620] RefSeq:NP_001122088.1 [DatabaseIdentifier:12293848] Pharos - Targets:Q9NR81 [DatabaseIdentifier:12277134] PRO:Q9NR81 [DatabaseIdentifier:12133682] OpenTargets:ENSG00000163947 [DatabaseIdentifier:11848990] HPA:ENSG00000163947-ARHGEF3 [DatabaseIdentifier:11833123] HMDB Protein:HMDBP11512 [DatabaseIdentifier:11796022] GeneCards:ARHGEF3 [DatabaseIdentifier:11708450] ENSEMBL:ENST00000338458 [DatabaseIdentifier:11708449] ENSEMBL:ENST00000296315 [DatabaseIdentifier:11708451] ENSEMBL:ENST00000413728 [DatabaseIdentifier:11585752] ENSEMBL:ENSP00000341071 [DatabaseIdentifier:11585751] ENSEMBL:ENSP00000410922 [DatabaseIdentifier:11585750] ENSEMBL:ENSP00000296315 [DatabaseIdentifier:11483625] ENSEMBL:ENSG00000163947
databaseName	UniProt
dbId	414718
description	recommendedName: Rho guanine nucleotide exchange factor 3 alternativeName: Exchange factor found in platelets and leukemic and neuronal tissues shortName: XPLN
displayName	UniProt:Q9NR81 ARHGEF3
geneName	ARHGEF3
identifier	Q9NR81
isSequenceChanged	false
keyword	Alternative splicing Cytoplasm Guanine-nucleotide releasing factor Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	ARHGEF3
otherIdentifier	11720860_s_at 11720861_a_at 11723491_a_at 11723492_a_at 16955291 218501_PM_at 218501_at 2677724 2677725 2677726 2677727 2677728 2677729 2677730 2677733 2677734 2677738 2677741 2677742 2677743 2677744 2677749 2677750 2677761 2677762 2677763 2677764 2677782 2677787 2677790 2677791 2677803 2677804 2677808 2677811 2677816 2677817 2677833 2677834 2677838 2677840 2677841 2677842 50650 51105_at 77800_at 8088247 A_23_P143885 GE62942 GO:0005085 GO:0005515 GO:0005737 GO:0005829 GO:0007266 GO:0035025 GO:0035556 GO:0051056 HMNXSV003040611 ILMN_1781010 PH_hs_0002285 g9506400_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2976629] ARHGEF3 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12694906] UCSC:Q9NR81 ARHGEF3 [ReferenceDNASequence:12117926] OMIM:612115 ARHGEF3 [ReferenceDNASequence:12062901] NCBI Gene:50650 ARHGEF3 [ReferenceDNASequence:11978808] Monarch:50650 ARHGEF3 [ReferenceDNASequence:11888940] KEGG:hsa:50650 ARHGEF3 [ReferenceDNASequence:11827727] HGNC:683 ARHGEF3 [ReferenceDNASequence:11429405] dbSNP Gene:50650 ARHGEF3 [ReferenceDNASequence:11425136] CTD Gene:50650 ARHGEF3 [ReferenceDNASequence:11393446] COSMIC - genes:ARHGEF3 ARHGEF3 [ReferenceDNASequence:11349019] BioGPS Gene:50650 ARHGEF3 [ReferenceDNASequence:ensembl:ENSG00000163947] ENSEMBL:ENSG00000163947 ARHGEF3
referenceTranscript	[ReferenceRNASequence:12574376] RefSeq:NM_019555.3 ARHGEF3 [ReferenceRNASequence:12574375] RefSeq:NM_001289698.1 ARHGEF3 [ReferenceRNASequence:12574373] RefSeq:XM_047448223.1 ARHGEF3 [ReferenceRNASequence:12574374] RefSeq:XM_047448222.1 ARHGEF3 [ReferenceRNASequence:12574372] RefSeq:NM_001377407.1 ARHGEF3 [ReferenceRNASequence:12574370] RefSeq:NM_001128615.2 ARHGEF3 [ReferenceRNASequence:12574369] RefSeq:NM_001128616.2 ARHGEF3 [ReferenceRNASequence:12574371] RefSeq:XM_047448224.1 ARHGEF3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ARHG3_HUMAN A8K5U7 Q4FZB6 Q4QQI5 Q4QQQ0 Q59F00 Q6NUN3 Q7Z4U2 Q7Z5T2 Q9H7T4
sequenceLength	526
species	[Species:48887] Homo sapiens
stId	uniprot:Q9NR81
url	http://purl.uniprot.org/uniprot/Q9NR81

Referrals

(interactor)	[UndirectedInteraction:11298519] UniProt:Q9NRD5 <-> UniProt:Q9NR81 (IntAct) [UndirectedInteraction:11157265] UniProt:P14373 <-> UniProt:Q9NR81 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2976629] ARHGEF3 [cytosol]

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