UniProt:Q9NQS3 NECTIN3

chain
  • signal peptide:1-57
  • chain:58-549
checksum 6D1104CCB4A9D731
comment
  • FUNCTION Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16216929). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16216929). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity).SUBUNIT Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT.SUBUNIT (Microbial infection) Interacts with C.difficile toxin TcdB, suggesting that it may contribute to TcdB toxin entry into cells (PubMed:26038560). It was however shown that NECTIN3/PVRL3 does not act as a major receptor for TcdB (PubMed:27680706).INTERACTION In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of supporting cells.ALTERNATIVE PRODUCTS Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.SIMILARITY Belongs to the nectin family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated C-terminus.
created [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference
databaseName UniProt
dbId 414691
description
  • recommendedName: Nectin-3 alternativeName: CDw113 alternativeName: fullName evidence="14"Nectin cell adhesion molecule 3 alternativeName: Poliovirus receptor-related protein 3 cdAntigenNameCD113/cdAntigenName
displayName UniProt:Q9NQS3 NECTIN3
geneName
  • NECTIN3
  • PRR3
  • PVRL3
identifier Q9NQS3
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell adhesion
  • Cell junction
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin domain
  • Membrane
  • Postsynaptic cell membrane
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Signal
  • Synapse
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • NECTIN3
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NECT3_HUMAN
  • E9PFR0
  • Q6NVZ3
  • Q8NC05
  • Q8WVU4
  • Q9BVA9
  • Q9Y412
sequenceLength 549
species [Species:48887] Homo sapiens
stId uniprot:Q9NQS3
url http://purl.uniprot.org/uniprot/Q9NQS3
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