UniProt:Q9NQ66 PLCB1

chain
  • chain:1-1216
checksum 6F4263D1A50C6FD1
comment
  • FUNCTION Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)COFACTOR Interacts with DGKQ.INTERACTION Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.ALTERNATIVE PRODUCTS Palmitoylated. Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier. Palmitoylation by ZDHHC21 is stimulated by inflammation.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 61694
description
  • recommendedName: fullName evidence="16"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 ecNumber evidence="11"3.1.4.11 alternativeName: PLC-154 alternativeName: Phosphoinositide phospholipase C-beta-1 alternativeName: Phospholipase C-I shortName: PLC-I alternativeName: Phospholipase C-beta-1 shortName: PLC-beta-1
displayName UniProt:Q9NQ66 PLCB1
geneName
  • PLCB1
  • KIAA0581
identifier Q9NQ66
isSequenceChanged false
keyword
  • Alternative splicing
  • Calcium
  • Cytoplasm
  • Epilepsy
  • Hydrolase
  • Lipid degradation
  • Lipid metabolism
  • Lipoprotein
  • Membrane
  • Nucleus
  • Palmitate
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transducer
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • PLCB1
otherIdentifier
  • 11730106_a_at
  • 11730107_a_at
  • 11730573_x_at
  • 16911283
  • 211925_PM_s_at
  • 211925_s_at
  • 213222_PM_at
  • 213222_at
  • 215687_PM_x_at
  • 215687_x_at
  • 23236
  • 35980_at
  • 3875643
  • 3875644
  • 3875645
  • 3875646
  • 3875647
  • 3875648
  • 3875653
  • 3875656
  • 3875694
  • 3875695
  • 3875750
  • 3875752
  • 3875753
  • 3875755
  • 3875756
  • 3875757
  • 3875758
  • 3875759
  • 3875761
  • 3875762
  • 3875763
  • 3875764
  • 3875765
  • 3875766
  • 3875769
  • 3875770
  • 3875771
  • 3875772
  • 3875784
  • 3875787
  • 3875788
  • 3875789
  • 3875790
  • 3875791
  • 3875794
  • 3875795
  • 3875796
  • 3875797
  • 3875798
  • 3875799
  • 3875800
  • 3875801
  • 3875802
  • 3875804
  • 3875805
  • 3875806
  • 3875807
  • 3875808
  • 3875809
  • 3875811
  • 3875812
  • 3875813
  • 3875815
  • 3875817
  • 3875823
  • 3875824
  • 3875840
  • 3875841
  • 3875842
  • 3875843
  • 3875853
  • 3875854
  • 3875855
  • 3875856
  • 3875857
  • 3875859
  • 3875860
  • 3875861
  • 3875862
  • 3875863
  • 42122_at
  • 8060854
  • 81002_at
  • A_14_P101690
  • A_14_P107318
  • A_14_P120757
  • A_14_P123667
  • A_14_P123700
  • A_14_P134332
  • A_21_P0009932
  • A_23_P6099
  • A_24_P941643
  • A_33_P3251193
  • A_33_P3251198
  • GE53290
  • GO:0000086
  • GO:0000785
  • GO:0004435
  • GO:0004629
  • GO:0005096
  • GO:0005509
  • GO:0005515
  • GO:0005516
  • GO:0005521
  • GO:0005546
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0006355
  • GO:0006629
  • GO:0007165
  • GO:0007186
  • GO:0007200
  • GO:0007207
  • GO:0007213
  • GO:0007215
  • GO:0007612
  • GO:0007613
  • GO:0008081
  • GO:0008277
  • GO:0010560
  • GO:0016020
  • GO:0016042
  • GO:0016607
  • GO:0016787
  • GO:0019899
  • GO:0021987
  • GO:0030154
  • GO:0031161
  • GO:0031965
  • GO:0032024
  • GO:0032735
  • GO:0032957
  • GO:0032991
  • GO:0034284
  • GO:0035556
  • GO:0035722
  • GO:0035723
  • GO:0040019
  • GO:0042802
  • GO:0043434
  • GO:0045444
  • GO:0045663
  • GO:0045892
  • GO:0045893
  • GO:0046330
  • GO:0046488
  • GO:0046872
  • GO:0048009
  • GO:0048015
  • GO:0048639
  • GO:0048856
  • GO:0050877
  • GO:0051209
  • GO:0055085
  • GO:0060466
  • GO:0070062
  • GO:0070498
  • GO:0080154
  • GO:0098772
  • GO:0098978
  • GO:0098982
  • GO:0099170
  • GO:0099178
  • GO:0099524
  • GO:0120548
  • GO:1900087
  • GO:1902618
  • GO:1903140
  • GO:1904117
  • GO:1904637
  • GO:1905631
  • GO:1990806
  • GO:2000344
  • GO:2000438
  • HMNXSV003007634
  • HMNXSV003027561
  • HMNXSV003046532
  • HMNXSV003050523
  • Hs.41143.0.S2_3p_at
  • Hs.41143.2.S1_3p_a_at
  • ILMN_1708432
  • ILMN_1723969
  • PH_hs_0025202
  • TC20000072.hg
  • TC20001091.hg
  • g9438228_3p_a_at
  • p21500
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PLCB1_HUMAN
  • D3DW12
  • D3DW13
  • O60325
  • Q17RQ6
  • Q5TFF7
  • Q5TGC9
  • Q8IV93
  • Q9BQW2
  • Q9H4H2
  • Q9H8H5
  • Q9NQ65
  • Q9NQH9
  • Q9NTH4
  • Q9UJP6
  • Q9UM26
sequenceLength 1216
species [Species:48887] Homo sapiens
stId uniprot:Q9NQ66
url http://purl.uniprot.org/uniprot/Q9NQ66
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