UniProt:Q9NP95 FGF20

chain
  • chain:1-211
checksum AB04608C16060CC1
comment
  • FUNCTION Neurotrophic factor that regulates central nervous development and function.SUBUNIT Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.SUBCELLULAR LOCATION Predominantly expressed in the cerebellum.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the heparin-binding growth factors family.CAUTION It is uncertain whether variants in this gene are associated with Parkinson disease. Some authors mention association with the disease (PubMed:18252210). In contrast, some others do not observe any association (PubMed:19133659).
crossReference
databaseName UniProt
dbId 54802
description
  • recommendedName: Fibroblast growth factor 20 shortName: FGF-20
displayName UniProt:Q9NP95 FGF20
geneName
  • FGF20
identifier Q9NP95
isSequenceChanged false
keyword
  • 3D-structure
  • Growth factor
  • Proteomics identification
  • Reference proteome
  • Secreted
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • FGF20
otherIdentifier
  • 11737349_a_at
  • 17074958
  • 220394_PM_at
  • 220394_at
  • 26281
  • 3125716
  • 3125717
  • 3125718
  • 3125719
  • 3125721
  • 3125722
  • 3125723
  • 3125724
  • 81080_at
  • 8149465
  • A_23_P395404
  • A_33_P3400248
  • GE82483
  • GO:0005102
  • GO:0005104
  • GO:0005576
  • GO:0005615
  • GO:0005737
  • GO:0007165
  • GO:0007267
  • GO:0008083
  • GO:0008284
  • GO:0008543
  • GO:0014059
  • GO:0022008
  • GO:0030154
  • GO:0030334
  • GO:0042491
  • GO:0043395
  • GO:0043410
  • GO:0043524
  • GO:0045664
  • GO:0048018
  • GO:0060043
  • GO:0070374
  • GO:0090722
  • GO:0098772
  • GO:1904340
  • HMNXSV003011026
  • ILMN_1788232
  • ILMN_2153061
  • PH_hs_0022971
  • PH_hs_0038278
  • TC08001010.hg
  • g9789946_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FGF20_HUMAN
  • B2RPH5
sequenceLength 211
species [Species:48887] Homo sapiens
stId uniprot:Q9NP95
url http://purl.uniprot.org/uniprot/Q9NP95
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