UniProt:Q9HD42 CHMP1A

chain
  • chain:1-196
checksum 85D0ED7D10828D60
comment
  • FUNCTION Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.SUBUNIT Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Self-associates. Interacts with CHMP1B. Interacts with VPS4A. Interacts with VPS4B. Interacts with PHF1. Interacts with IST1. Interacts with MITD1.INTERACTION The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.ALTERNATIVE PRODUCTS Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63.INDUCTION By muristerone.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SNF7 family.CAUTION Was originally (PubMed:8863740) thought to be a metalloprotease (PRSM1). This was based on a wrong translation of the ORF which gave rise to a putative protein of 318 AA containing a pattern reminiscent of zinc metalloproteases.SEQUENCE CAUTION Wrong choice of frame.SEQUENCE CAUTION Wrong choice of frame.
created [InstanceEdit:184440] D'Eustachio, P, 2006-07-27 16:05:42
crossReference
databaseName UniProt
dbId 184301
description
  • recommendedName: Charged multivesicular body protein 1a alternativeName: Chromatin-modifying protein 1a shortName: CHMP1a alternativeName: Vacuolar protein sorting-associated protein 46-1 shortName: Vps46-1 shortName: hVps46-1
displayName UniProt:Q9HD42 CHMP1A
geneName
  • CHMP1A
  • CHMP1
  • KIAA0047
  • PCOLN3
  • PRSM1
identifier Q9HD42
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cell cycle
  • Cell division
  • Coiled coil
  • Cytoplasm
  • Endosome
  • Membrane
  • Neurodegeneration
  • Nucleus
  • Phosphoprotein
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • CHMP1A
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CHM1A_HUMAN
  • A2RU09
  • Q14468
  • Q15779
  • Q96G31
sequenceLength 196
species [Species:48887] Homo sapiens
stId uniprot:Q9HD42
url http://purl.uniprot.org/uniprot/Q9HD42

Referrals

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